SCHEMBL18856430

SCHEMBL18856430

Cc1cc(C(c2ccc(C#N)cc2)c2cncn2C)cc2c(C#N)c(Cc3ccc(-n4cccn4)cc3)c(C#N)nc12

nearest known ligand 0.68

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
RORC P51449 19/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16460673 0.81 RORC (1.00) RORC
SCHEMBL16639547 0.78 RORC (0.66) RORC
SCHEMBL16632957 0.75 RORC (0.88) RORC
SCHEMBL21574688 0.74 RORC (0.49) RORC
SCHEMBL16479512 0.74 RORC (0.84) RORC
SCHEMBL21574711 0.73 RORC (0.60) RORC
SCHEMBL16460270 0.73 RORC (1.00) RORC
SCHEMBL16633130 0.73 RORC (0.86) RORC
SCHEMBL22726350 0.71 RORC (0.43) RORC
SCHEMBL16639473 0.71 RORC (0.81) RORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2909192-B1 METHYLENE LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T JANSSEN PHARMACEUTICA NV (BE) 2017-05-17 EP disclosed