Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.49 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.45 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18838368 | 0.82 | CARM1 (0.46) | SCN9ACARM1PRMT6KMT2AMEN1 | |
| SCHEMBL18838344 | 0.82 | CYP2D6 (0.46) | SCN9ACARM1PRMT6KMT2AALDH1A1 | |
| SCHEMBL18838506 | 0.82 | HTR2A (0.54) | KMT2AHDAC1HDAC6MEN1ADRA1A | |
| SCHEMBL18838471 | 0.81 | KCNH2 (0.56) | KMT2AALDH1A1HDAC1HDAC6MEN1 | |
| SCHEMBL18838296 | 0.79 | EZH2 (0.45) | SCN9ANPC1RAB9AEZH2KMT2A | |
| SCHEMBL18838394 | 0.78 | LMNA (0.43) | SCN9ACARM1PRMT6NPC1KMT2A | |
| SCHEMBL9566447 | 0.77 | HDAC1 (0.50) | KMT2AHDAC1HDAC6MEN1 | |
| SCHEMBL18838340 | 0.76 | SMN1; SMN2 (0.51) | NPC1RAB9AKMT2AHDAC1HDAC6 | |
| SCHEMBL18838388 | 0.74 | KCNH2 (0.46) | SCN9ACARM1PRMT6 | |
| SCHEMBL363917 | 0.74 | CARM1 (0.69) | CARM1PRMT6NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017083867-A1 | ION CHANNEL INHIBITORY COMPOUNDS, PHARMACEUTICAL FORMULATIONS AND USES | AFASCI, INC. (US) | 2017-05-18 | — | — | WO | disclosed |