Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.60 |
| ▸ | KDR | P35968 | 4/20 | 0.59 |
| ▸ | FBP1 | P09467 | 2/20 | 0.59 |
| ▸ | CLK1 | P49759 | 2/20 | 0.59 |
| ▸ | RET | P07949 | 2/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.59 |
| ▸ | INSR | P06213 | 1/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.59 |
| ▸ | FLT4 | P35916 | 1/20 | 0.59 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.59 |
| ▸ | TEK | Q02763 | 1/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.59 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.59 |
| ▸ | KIF5B | P33176 | 1/20 | 0.59 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.59 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.55 |
| ▸ | LCK | P06239 | 2/20 | 0.54 |
| ▸ | FLT1 | P17948 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18862788 | 0.88 | EGFR (0.60) | EGFRKDRFBP1CLK1RET | |
| SCHEMBL12846249 | 0.85 | EGFR (0.64) | EGFRKDRFBP1CLK1RET | |
| SCHEMBL26876 | 0.84 | EGFR (0.83) | EGFRKDRFBP1CLK1AURKA | |
| SCHEMBL29362232 | 0.84 | EGFR (0.83) | EGFRKDRFBP1CLK1AURKA | |
| SCHEMBL6792594 | 0.83 | EGFR (0.74) | EGFRKDRFBP1CLK1RET | |
| SCHEMBL18862789 | 0.83 | EGFR (0.63) | EGFRKDRFBP1CLK1RET | |
| Hydrochloric Acid SCHEMBL28101874 | 0.83 | EGFR (0.81) | EGFRKDRFBP1CLK1AURKA | |
| Water SCHEMBL28549003 | 0.83 | EGFR (0.81) | EGFRKDRFBP1CLK1AURKA | |
| SCHEMBL18033827 | 0.83 | EGFR (0.56) | EGFRKDRFBP1CLK1RET | |
| SCHEMBL14388216 | 0.81 | EGFR (0.56) | EGFRKDRFBP1CLK1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2716633-B1 | QUINAZOLINE DERIVATIVE AS TYROSINE-KINASE INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | XUANZHU PHARMA CO LTD (CN) | 2017-05-17 | — | — | EP | disclosed |