Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.56 |
| ▸ | FBP1 | P09467 | 2/20 | 0.56 |
| ▸ | RET | P07949 | 2/20 | 0.54 |
| ▸ | KDR | P35968 | 3/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.53 |
| ▸ | INSR | P06213 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | FLT4 | P35916 | 1/20 | 0.53 |
| ▸ | CLK1 | P49759 | 1/20 | 0.53 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.53 |
| ▸ | TEK | Q02763 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.53 |
| ▸ | KIF5B | P33176 | 1/20 | 0.53 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18033825 | 0.90 | EGFR (0.67) | EGFRFBP1RETKDRAURKA | |
| SCHEMBL18033824 | 0.90 | EGFR (0.67) | EGFRFBP1RETKDRAURKA | |
| SCHEMBL15217652 | 0.84 | FBP1 (0.78) | EGFRFBP1KDRAURKAERBB2 | |
| SCHEMBL18862763 | 0.83 | EGFR (0.60) | EGFRFBP1RETKDRAURKA | |
| SCHEMBL18862788 | 0.82 | EGFR (0.60) | EGFRFBP1RETKDRAURKA | |
| SCHEMBL25707230 | 0.81 | RET (0.68) | EGFRFBP1RETKDRAURKA | |
| SCHEMBL18033826 | 0.81 | EGFR (0.55) | EGFRFBP1RETKDRAURKA | |
| SCHEMBL14863005 | 0.80 | EGFR (0.84) | EGFRFBP1KDRAURKAERBB2 | |
| SCHEMBL25735856 | 0.79 | RET (0.55) | EGFRFBP1RETKDRAURKA | |
| SCHEMBL14387986 | 0.78 | FBP1 (0.59) | EGFRFBP1AURKAERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2634178-B1 | QUINAZOLINE DERIVATIVE AND QUINAZOLINE COMPLEX PROTEIN KINASE INHIBITOR FOR INHIBITING MULTIPLICATION OF TUMOR CELLS AND PREPARATION METHOD THEREOF | CHINESE ACAD INST CHEMISTRY (CN) | 2016-08-24 | — | — | EP | disclosed |