Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.48 |
| ▸ | CCR1 | P32246 | 1/20 | 0.48 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.48 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1877321 | 0.88 | SMN1; SMN2 (0.49) | THRBSMN1; SMN2KCNE1CCR1KCNQ1 | |
| SCHEMBL4555867 | 0.88 | SMN1; SMN2 (0.48) | THRBSMN1; SMN2KCNE1CCR1KCNQ1 | |
| SCHEMBL4637379 | 0.88 | SMN1; SMN2 (0.48) | THRBSMN1; SMN2KCNE1CCR1KCNQ1 | |
| SCHEMBL12952653 | 0.87 | SMN1; SMN2 (0.47) | THRBSMN1; SMN2KCNE1CCR1KCNQ1 | |
| SCHEMBL1881737 | 0.87 | SMN1; SMN2 (0.47) | THRBSMN1; SMN2KCNE1CCR1KCNQ1 | |
| SCHEMBL1874288 | 0.87 | SMN1; SMN2 (0.47) | THRBSMN1; SMN2KCNE1CCR1KCNQ1 | |
| SCHEMBL1881581 | 0.85 | KCNH2 (0.46) | THRBSMN1; SMN2KCNE1CCR1KCNQ1 | |
| SCHEMBL1881234 | 0.84 | KCNH2 (0.46) | THRBSMN1; SMN2KCNE1CCR1KCNQ1 | |
| SCHEMBL1875688 | 0.83 | HDAC1 (0.49) | SMN1; SMN2ERCC1FEN1ERCC4MEN1 | |
| SCHEMBL1877381 | 0.83 | SMN1; SMN2 (0.46) | RXFP1SMN1; SMN2ERCC1FEN1ERCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937678-B1 | HIV INTEGRASE INHIBITORS | ANGELETTI P IST RICHERCHE BIO (IT) | 2011-07-27 | — | — | EP | claimed |
| US-7939537-B2 | HIV integrase inhibitors | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2011-05-10 | — | — | US | claimed |