Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.47 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.47 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.44 |
| ▸ | CCR1 | P32246 | 1/20 | 0.44 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | CALCA | P06881 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1886479 | 0.88 | THRB (0.57) | SMN1; SMN2ERCC1FEN1ERCC4KCNE1 | |
| SCHEMBL12952653 | 0.88 | SMN1; SMN2 (0.47) | SMN1; SMN2ERCC1FEN1ERCC4KCNE1 | |
| SCHEMBL1877321 | 0.87 | SMN1; SMN2 (0.49) | SMN1; SMN2ERCC1FEN1ERCC4KCNE1 | |
| SCHEMBL4637379 | 0.86 | SMN1; SMN2 (0.48) | SMN1; SMN2ERCC1FEN1ERCC4KCNE1 | |
| SCHEMBL1874288 | 0.85 | SMN1; SMN2 (0.47) | SMN1; SMN2ERCC1FEN1ERCC4KCNE1 | |
| SCHEMBL1881737 | 0.85 | SMN1; SMN2 (0.47) | SMN1; SMN2ERCC1FEN1ERCC4KCNE1 | |
| SCHEMBL1877381 | 0.84 | SMN1; SMN2 (0.46) | SMN1; SMN2ERCC1FEN1ERCC4MEN1 | |
| SCHEMBL1881581 | 0.84 | KCNH2 (0.46) | SMN1; SMN2ERCC1FEN1ERCC4KCNE1 | |
| SCHEMBL1875688 | 0.84 | HDAC1 (0.49) | SMN1; SMN2ERCC1FEN1ERCC4MEN1 | |
| SCHEMBL1881234 | 0.83 | KCNH2 (0.46) | SMN1; SMN2ERCC1FEN1ERCC4KCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114903-A1 | BICYCLIC PYRIMIDINONES AND USES THEREOF | Avexa Limited (AU) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008077188-A1 | BICYCLIC PYRIMIDINONES AND USES THEREOF | AVEXA LIMITED (AU) | 2008-07-03 | — | — | WO | disclosed |