Carboxyamidotriazole

Carboxyamidotriazole

SCHEMBL18866

NC(=O)c1nnn(Cc2cc(Cl)c(C(=O)c3ccc(Cl)cc3)c(Cl)c2)c1N

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 4/20 1.00
GALR3 O60755 1/20 1.00
CYP3A4 P08684 1/20 1.00
CYP2C9 P11712 1/20 1.00
NR2F2 P24468 1/20 1.00
HIF1A Q16665 1/20 1.00
HPGD P15428 1/20 0.48
NPC1 O15118 2/20 0.48
RAB9A P51151 2/20 0.48
HTT P42858 1/20 0.47
MAPT P10636 6/20 0.46
CYP1A2 P05177 1/20 0.44
TSHR P16473 2/20 0.43
KMT2A Q03164 1/20 0.43
KCNH2 Q12809 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Carboxyamidotriazole SCHEMBL8467240 0.99 SMN1; SMN2 (0.98) SMN1; SMN2GALR3CYP3A4CYP2C9NR2F2
SCHEMBL17507850 0.93 SMN1; SMN2 (0.88) SMN1; SMN2GALR3CYP3A4CYP2C9NR2F2
SCHEMBL7264241 0.92 SMN1; SMN2 (0.86) SMN1; SMN2GALR3CYP3A4CYP2C9NR2F2
SCHEMBL12795019 0.91 SMN1; SMN2 (0.83) SMN1; SMN2GALR3CYP3A4CYP2C9NR2F2
SCHEMBL7280524 0.91 SMN1; SMN2 (0.83) SMN1; SMN2GALR3CYP3A4CYP2C9NR2F2
SCHEMBL28938726 0.90 SMN1; SMN2 (0.81) SMN1; SMN2GALR3CYP3A4CYP2C9NR2F2
SCHEMBL7271739 0.90 SMN1; SMN2 (0.81) SMN1; SMN2GALR3CYP3A4CYP2C9NR2F2
SCHEMBL7265907 0.89 SMN1; SMN2 (0.80) SMN1; SMN2GALR3CYP3A4CYP2C9NR2F2
SCHEMBL7264526 0.89 SMN1; SMN2 (0.80) SMN1; SMN2GALR3CYP3A4CYP2C9NR2F2
SCHEMBL7264556 0.88 SMN1; SMN2 (0.78) SMN1; SMN2GALR3CYP3A4CYP2C9NR2F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 13453 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4735045-A2 OXAZAPHOSPHORINE ANTIBODY DRUG CONJUGATES AND METHODS OF USE La Life Products, LLC (US) 2026-05-06 EP claimed
US-12594262-B2 CAI nanoemulsions FORWARDVUE PHARMA, INC. (US) 2026-04-07 US claimed
EP-4717275-A1 ANTI-LUNG CANCER COMBINED DRUG AND USE THEREOF Gunagdong Yinzhu Pharmaceutical Technology Co., Ltd (CN) 2026-04-01 EP claimed
US-20260076969-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2026-03-19 US claimed
EP-4192452-B1 COMPOSITIONS COMPRISING CARBOXYAMIDOTRIAZOLE OROTATE FOR USE IN PREVENTING OR TREATING SARS-COV-2 INFECTION TACTICAL THERAPEUTICS INC (US) 2025-10-08 EP claimed
US-12364682-B2 Use of tegaserod in preparation of anti-tumor drug QINGDAO HAIJI BIOMEDICINE CO., LTD. (CN) 2025-07-22 US claimed
US-20250170082-A1 HPDL INHIBITORS AND USES THEREOF NEW YORK UNIVERSITY (US) 2025-05-29 US claimed
CN-119977778-A Preparation method of carboxyamidotriazole intermediate 广东银珠医药科技有限公司 2025-05-13 CN claimed
CN-119971050-A Composition of carboxyamidotriazole and chemotherapeutic drug and application of composition in combination treatment of solid tumors 广东银珠医药科技有限公司 2025-05-13 CN claimed
WO-2025085311-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF KMT2D-DEFICIENT CANCERS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2025-04-24 WO claimed
US-5861406-A ANTICARCINOGENIC AGENTS AND ANTITUMOR AGENTS CONSTANTIA GRUPPE (AT) 1999-01-19 US claimed
EP-0840608-A1 TREATMENT AND PREVENTION OF NEOPLASMS WITH SALTS OF AMINOIMIDAZOLE CARBOXAMIDE AND 5-AMINO OR SUBSTITUTED AMINO 1,2,3-TRIAZOLES Constantia Gruppe (AT) 1998-05-13 EP claimed
EP-0797438-A1 INHIBITION OF RETROVIRAL LTR PROMOTERS BY CALCIUM RESPONSE MODIFIERS THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1997-10-01 EP claimed
WO-1997003668-A1 TREATMENT AND PREVENTION OF NEOPLASMS WITH SALTS OF AMINOIMIDAZOLE CARBOXAMIDE AND 5-AMINO OR SUBSTITUTED AMINO 1,2,3-TRIAZOLES CONSTANTIA GRUPPE (AT) 1997-02-06 WO claimed
US-5565478-A Combination therapy using signal transduction inhibitors with paclitaxel and other taxane analogs THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH & HUMAN SERVICES (US) 1996-10-15 US claimed
WO-1996018394-A1 INHIBITION OF RETROVIRAL LTR PROMOTERS BY CALCIUM RESPONSE MODIFIERS THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OFHEALTH AND HUMAN SERVICES (US) 1996-06-20 WO claimed
EP-0304221-B1 5-amino or substituted amino 1,2,3-triazoles useful as antiproliferative agents MERCK & CO INC (US) 1994-02-16 EP claimed
US-5045543-A Treatment of cancer with high probability of metastasis MERCK & CO., INC. (US) 1991-09-03 US claimed
EP-0304221-A2 5-amino or substituted amino 1,2,3-triazoles useful as antiproliferative agents MERCK & CO. INC. (US) 1989-02-22 EP claimed
US-4590201-A ANTICOCCIDIAL AGENT FOR ANIMALS PARTICULARLY FOR POULTRY MERCK & CO., INC. (US) 1986-05-20 US claimed