Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.48 |
| ▸ | MMP9 | P14780 | 2/20 | 0.48 |
| ▸ | ANPEP | P15144 | 2/20 | 0.48 |
| ▸ | LTA4H | P09960 | 2/20 | 0.48 |
| ▸ | LAP3 | P28838 | 1/20 | 0.48 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.48 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.48 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 11/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1886605 | 1.00 | MMP2 (0.48) | MMP2MMP9ANPEPLTA4HLAP3 | |
| SCHEMBL1491343 | 0.90 | HDAC6 (0.48) | MMP2MMP9ANPEPLTA4HLAP3 | |
| SCHEMBL1491338 | 0.90 | HDAC6 (0.48) | MMP2MMP9ANPEPLTA4HLAP3 | |
| SCHEMBL12673047 | 0.85 | HDAC6 (0.55) | LTA4HHDAC1HDAC6HDAC3HDAC8 | |
| Tefinostat SCHEMBL1491467 | 0.85 | HDAC1 (0.48) | MMP2MMP9ANPEPLTA4HLAP3 | |
| Tefinostat SCHEMBL1491564 | 0.85 | HDAC1 (0.48) | MMP2MMP9ANPEPLTA4HLAP3 | |
| Tefinostat SCHEMBL1491466 | 0.85 | HDAC1 (0.48) | MMP2MMP9ANPEPLTA4HLAP3 | |
| SCHEMBL1491326 | 0.83 | HDAC1 (0.46) | MMP2MMP9ANPEPLTA4HLAP3 | |
| SCHEMBL1491328 | 0.83 | HDAC1 (0.46) | MMP2MMP9ANPEPLTA4HLAP3 | |
| SCHEMBL1491503 | 0.83 | HDAC6 (0.60) | LTA4HHDAC1HDAC6HDAC3HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130116318-A1 | Enzyme Inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2013-05-09 | — | — | US | disclosed |
| US-7939666-B2 | Enzyme inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2011-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130116318-A1 | Enzyme Inhibitors | HDAC1, HDAC11, HDAC7 | MMP2 59/4885MMP9 77/4885ANPEP 1051/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.