⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18866614 | 1.00 | — | — | |
| Trifluoroacetic Acid SCHEMBL20560902 | 0.94 | PRSS1 (0.49) | — | |
| SCHEMBL5862742 | 0.91 | F2 (0.42) | — | |
| SCHEMBL18866508 | 0.90 | NPC1 (0.45) | — | |
| SCHEMBL18866615 | 0.90 | NPC1 (0.45) | — | |
| SCHEMBL22850490 | 0.90 | ALDH1A1 (0.46) | — | |
| Trifluoroacetic Acid SCHEMBL20560905 | 0.87 | PRSS1 (0.49) | — | |
| SCHEMBL14127426 | 0.86 | PRSS1 (0.48) | — | |
| SCHEMBL5861563 | 0.86 | PRSS1 (0.43) | — | |
| SCHEMBL24115406 | 0.85 | F2 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10906881-B2 | Inhibitors of arginine gingipain | Cortexyme, Inc. (US) | 2021-02-02 | — | — | US | disclosed |
| US-10906881-B2 | Inhibitors of arginine gingipain | Cortexyme, Inc. (US) | 2021-02-02 | — | — | US | disclosed |
| US-20180334440-A1 | INHIBITORS OF ARGININE GINGIPAIN | Cortexyme, Inc. (US) | 2018-11-22 | — | — | US | disclosed |
| WO-2017083433-A1 | INHIBITORS OF ARGININE GINGIPAIN | Cortexyme, Inc. (US) | 2017-05-18 | — | — | WO | disclosed |