Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK4 | Q9P2K8 | 2/20 | 0.51 |
| ▸ | GSK3A | P49840 | 6/20 | 0.43 |
| ▸ | GSK3B | P49841 | 6/20 | 0.43 |
| ▸ | AURKA | O14965 | 4/20 | 0.43 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 7/20 | 0.38 |
| ▸ | JAK3 | P52333 | 3/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16246069 | 0.91 | EIF2AK4 (0.51) | EIF2AK4GSK3AGSK3BAURKAMAPK6 | |
| SCHEMBL16245588 | 0.90 | EIF2AK4 (0.51) | EIF2AK4GSK3AGSK3BAURKAMAPK6 | |
| SCHEMBL17821168 | 0.83 | EIF2AK4 (0.50) | EIF2AK4GSK3AGSK3BAURKAMAPK6 | |
| SCHEMBL16245534 | 0.82 | GSK3A (0.57) | EIF2AK4GSK3AGSK3BAURKAMAPK6 | |
| SCHEMBL17821175 | 0.81 | EIF2AK4 (0.56) | EIF2AK4GSK3AGSK3BAURKAMAPK6 | |
| SCHEMBL16264861 | 0.80 | EIF2AK4 (0.55) | EIF2AK4GSK3AGSK3BAURKAMAPK6 | |
| SCHEMBL17821176 | 0.80 | EIF2AK4 (0.55) | EIF2AK4GSK3AGSK3BAURKAMAPK6 | |
| SCHEMBL16245585 | 0.79 | EIF2AK4 (0.47) | EIF2AK4GSK3AGSK3BAURKAMAPK6 | |
| SCHEMBL16246065 | 0.77 | EIF2AK4 (0.51) | EIF2AK4GSK3AGSK3BAURKAMAPK6 | |
| SCHEMBL16246066 | 0.75 | EIF2AK4 (0.51) | EIF2AK4GSK3AGSK3BAURKAMAPK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994471-B1 | MACROCYCLES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2017-05-17 | — | — | EP | disclosed |