SCHEMBL18869397

SCHEMBL18869397

CC(=O)CCCCOc1ccc(N)cc1

nearest known ligand 0.55

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.55
GAA P10253 1/20 0.53
TDP1 Q9NUW8 2/20 0.49
TSHR P16473 2/20 0.47
PPARA Q07869 2/20 0.45
HDAC1 Q13547 2/20 0.44
HDAC3 O15379 1/20 0.44
HDAC4 P56524 1/20 0.44
HDAC7 Q8WUI4 1/20 0.44
HDAC2 Q92769 1/20 0.44
HDAC10 Q969S8 1/20 0.44
HDAC11 Q96DB2 1/20 0.44
HDAC8 Q9BY41 1/20 0.44
HDAC6 Q9UBN7 1/20 0.44
HDAC9 Q9UKV0 1/20 0.44
HDAC5 Q9UQL6 1/20 0.44
TP53 P04637 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5191886 0.89 TDP1 (0.52) L3MBTL1GAATDP1TSHRTP53
SCHEMBL16245586 0.84 PPARA (0.63) L3MBTL1GAAPPARAHDAC1HDAC3
SCHEMBL8117338 0.84 TDP1 (0.50) L3MBTL1GAATDP1TSHR
SCHEMBL28655996 0.83 MEN1 (0.53) L3MBTL1GAATDP1HDAC1HDAC3
SCHEMBL24935937 0.82 GAA (0.58) L3MBTL1GAAPPARAHDAC1HDAC3
SCHEMBL25794785 0.82 NR5A1 (0.62) L3MBTL1GAATSHRHDAC1HDAC3
SCHEMBL17265696 0.82 PPARA (0.61) L3MBTL1PPARAHDAC1HDAC3HDAC4
SCHEMBL25794749 0.82 NR5A1 (0.62) L3MBTL1GAATSHRHDAC1HDAC3
SCHEMBL839412 0.82 PPARA (0.61) L3MBTL1PPARAHDAC1HDAC3HDAC4
SCHEMBL15887764 0.82 NR5A1 (0.62) L3MBTL1GAATSHRHDAC1HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2994471-B1 MACROCYCLES AS KINASE INHIBITORS MERCK PATENT GMBH (DE) 2017-05-17 EP disclosed