Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.43 |
| ▸ | CDK2 | P24941 | 3/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.43 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13952701 | 1.00 | POLB (0.60) | POLBKDM4EGRM5LMNARAB9A | |
| SCHEMBL3155175 | 0.82 | POLB (0.73) | POLBKDM4ELMNARAB9AHTT | |
| Hydrochloric Acid SCHEMBL3258168 | 0.81 | POLB (0.71) | POLBKDM4ELMNARAB9AHTT | |
| SCHEMBL1890332 | 0.80 | RAB9A (0.51) | POLBLMNARAB9AFFAR2HTT | |
| SCHEMBL1886982 | 0.79 | POLB (0.54) | POLBKDM4EGRM5LMNARAB9A | |
| SCHEMBL1887457 | 0.77 | PTGS1 (0.43) | POLBKDM4ELMNAALDH1A1MAPT | |
| SCHEMBL1892950 | 0.77 | PTGS1 (0.43) | POLBKDM4ELMNAALDH1A1MAPT | |
| SCHEMBL24932435 | 0.77 | POLB (1.00) | POLBLMNARAB9ACCNA2CDK2 | |
| SCHEMBL24932269 | 0.77 | POLB (1.00) | POLBLMNARAB9ACCNA2CDK2 | |
| SCHEMBL1885903 | 0.76 | KDM4E (0.44) | POLBKDM4ELMNAHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856031-B1 | 2-ARYLPROPIONIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPE PHA R MA SPA RES & MFG (IT) | 2009-02-25 | — | — | EP | claimed |
| US-7939521-B2 | 2-arylpropionic acid derivatives and pharmaceutical compositions containing them | DompePHA.R.MA S.p.A. (IT) | 2011-05-10 | — | — | US | disclosed |
| US-7939521-B2 | 2-arylpropionic acid derivatives and pharmaceutical compositions containing them | DompePHA.R.MA S.p.A. (IT) | 2011-05-10 | — | — | US | disclosed |
| US-7939521-B2 | 2-arylpropionic acid derivatives and pharmaceutical compositions containing them | DompePHA.R.MA S.p.A. (IT) | 2011-05-10 | — | — | US | disclosed |
| EP-1856031-B1 | 2-ARYLPROPIONIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPE PHA R MA SPA RES & MFG (IT) | 2009-02-25 | — | — | EP | disclosed |
| US-20080312293-A1 | 2-Arylpropionic Acid Derivatives and Pharmaceutical Compositions Containing Them | DOMPE' PHA.R.MA.S.P.A. (IT) | 2008-12-18 | — | — | US | disclosed |
| US-20080312293-A1 | 2-Arylpropionic Acid Derivatives and Pharmaceutical Compositions Containing Them | DOMPE' PHA.R.MA.S.P.A. (IT) | 2008-12-18 | — | — | US | disclosed |
| US-20080312293-A1 | 2-Arylpropionic Acid Derivatives and Pharmaceutical Compositions Containing Them | DOMPE' PHA.R.MA.S.P.A. (IT) | 2008-12-18 | — | — | US | disclosed |
| EP-1856031-A1 | 2-ARYLPROPIONIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPE' pha.r.ma s.p.a. (IT) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006063999-A1 | 2-ARYLPROPIONIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPE' PHA.R.MA.S.P.A. (IT) | 2006-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312293-A1 | 2-Arylpropionic Acid Derivatives and Pharmaceutical Compositions Containing Them | C3AR1, C5AR2, C5AR1 | POLB 2510/4885KDM4E 4711/4885GRM5 820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.