Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | DHFR | P00374 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.42 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14123348 | 0.87 | KMT2A (0.56) | KMT2ANPC1RAB9AMEN1DHFR | |
| SCHEMBL18869827 | 0.79 | CYP2C19 (0.40) | KMT2ARAB9AMEN1TP53MAPT | |
| SCHEMBL14135200 | 0.79 | MEN1 (0.59) | KMT2ANPC1RAB9AMEN1DHFR | |
| SCHEMBL18869954 | 0.79 | DRD2 (0.35) | TP53MAPTGAAHRH1 | |
| SCHEMBL14853095 | 0.78 | MEN1 (0.60) | KMT2ANPC1RAB9AMEN1DHFR | |
| SCHEMBL28169331 | 0.76 | MEN1 (0.61) | KMT2ANPC1RAB9AMEN1DHFR | |
| SCHEMBL6772037 | 0.75 | MEN1 (0.60) | KMT2ANPC1RAB9AMEN1DHFR | |
| SCHEMBL13226236 | 0.75 | MEN1 (0.60) | KMT2ANPC1RAB9AMEN1DHFR | |
| SCHEMBL21065437 | 0.75 | MEN1 (0.56) | KMT2ANPC1RAB9AMEN1DHFR | |
| SCHEMBL20319348 | 0.74 | MEN1 (0.38) | KMT2ANPC1RAB9AMEN1DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9650391-B2 | N3-heteroaryl substituted triazoles and N5-heteroaryl substituted triazoles useful as Axl inhibitors | RIGEL PHARMACEUTICALS INC. (US) | 2017-05-16 | — | — | US | disclosed |