Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 20/20 | 0.70 |
| ▸ | CXCR1 | P25024 | 17/20 | 0.70 |
| ▸ | CCR7 | P32248 | 4/20 | 0.70 |
| ▸ | CCR6 | P51684 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Navarixin Anhydrous SCHEMBL184744 | 0.82 | CXCR2 (1.00) | CXCR2CXCR1CCR7CCR6 | |
| Navarixin Anhydrous SCHEMBL12262719 | 0.82 | CXCR2 (1.00) | CXCR2CXCR1CCR7CCR6 | |
| Navarixin Anhydrous SCHEMBL1446663 | 0.82 | CXCR2 (1.00) | CXCR2CXCR1CCR7CCR6 | |
| Navarixin Anhydrous SCHEMBL2024683 | 0.81 | CXCR2 (0.98) | CXCR2CXCR1CCR7CCR6 | |
| Navarixin Anhydrous SCHEMBL2024684 | 0.81 | CXCR2 (0.98) | CXCR2CXCR1CCR7CCR6 | |
| SCHEMBL13208128 | 0.79 | CXCR2 (1.00) | CXCR2CXCR1CCR7CCR6 | |
| SCHEMBL13436971 | 0.78 | CXCR2 (0.65) | CXCR2CXCR1CCR7CCR6 | |
| SCHEMBL13436957 | 0.78 | CXCR2 (0.64) | CXCR2CXCR1CCR7CCR6 | |
| SCHEMBL12310859 | 0.78 | CXCR2 (0.64) | CXCR2CXCR1CCR7CCR6 | |
| SCHEMBL13405672 | 0.78 | CXCR2 (0.69) | CXCR2CXCR1CCR7CCR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2178826-B1 | PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF 1,2-SUBSTITUTED 3,4-DIOXO-1-CYCLOBUTENE COMPOUNDS | MERCK SHARP & DOHME (US) | 2017-05-17 | — | — | EP | disclosed |