Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Navarixin Anhydrous. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 known ✓ | P25025 | 20/20 | 0.98 |
| ▸ | CXCR1 known ✓ | P25024 | 17/20 | 0.98 |
| ▸ | CCR7 | P32248 | 3/20 | 0.98 |
| ▸ | CCR6 | P51684 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Navarixin Anhydrous SCHEMBL2024684 | 1.00 | CXCR2 (0.98) | CXCR2CXCR1CCR7CCR6 | |
| Navarixin Anhydrous SCHEMBL184744 | 0.99 | CXCR2 (1.00) | CXCR2CXCR1CCR7CCR6 | |
| Navarixin Anhydrous SCHEMBL1446663 | 0.99 | CXCR2 (1.00) | CXCR2CXCR1CCR7CCR6 | |
| Navarixin Anhydrous SCHEMBL12262719 | 0.99 | CXCR2 (1.00) | CXCR2CXCR1CCR7CCR6 | |
| SCHEMBL12263105 | 0.89 | CXCR2 (0.81) | CXCR2CXCR1CCR7CCR6 | |
| SCHEMBL12087147 | 0.89 | CXCR2 (0.81) | CXCR2CXCR1CCR7CCR6 | |
| SCHEMBL12262817 | 0.89 | CXCR2 (1.00) | CXCR2CXCR1CCR7CCR6 | |
| SCHEMBL248562 | 0.89 | CXCR2 (1.00) | CXCR2CXCR1CCR7CCR6 | |
| SCHEMBL12574856 | 0.89 | CXCR2 (1.00) | CXCR2CXCR1CCR7CCR6 | |
| SCHEMBL12262770 | 0.89 | CXCR2 (1.00) | CXCR2CXCR1CCR7CCR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8519168-B2 | Process and intermediates for the synthesis of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds | MERCK SHARP & DOHME CORP. (US) | 2013-08-27 | — | — | US | disclosed |
| US-20110160469-A1 | PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF 1,2-SUBSTITUTED 3,4-DIOXO-1-CYCLOBUTENE COMPOUNDS | MERCK SHARP & DOHME LLC | 2011-06-30 | — | — | US | disclosed |
| US-20100249439-A1 | PROCESS FOR CONTROLLED CRYSTAL SIZE IN 1,2-SUBSTITUTED 3,4-DIOXO-1-CYCLOBUTENE COMPOUNDS | MERCK SHARP & DOHME CORP. | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110160469-A1 | PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF 1,2-SUBSTITUTED 3,4-DIOXO-1-CYCLOBUTENE COMPOUNDS | CCL2, CCR1, CXCR1 | CXCR2 5/4885CXCR1 3/4885CCR7 22/4885 |
| US-20100249439-A1 | PROCESS FOR CONTROLLED CRYSTAL SIZE IN 1,2-SUBSTITUTED 3,4-DIOXO-1-CYCLOBUTENE COMPOUNDS | CCL2, CCL5, CCR1 | CXCR2 7/4885CXCR1 5/4885CCR7 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.