Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.47 |
| ▸ | CCL2 | P13500 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 2/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | BRD2 | P25440 | 3/20 | 0.39 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.39 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TAF1 | P21675 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.39 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.39 |
| ▸ | TAF1L | Q8IZX4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18871993 | 0.93 | BRD4 (0.47) | BRD4HRH3GABRA5GRM5BRD2 | |
| SCHEMBL13724338 | 0.88 | BRD4 (0.62) | BRD4CCL2BRD2BRD3TRIM24 | |
| SCHEMBL15437363 | 0.80 | BRD4 (0.63) | BRD4CCL2BRD2BRD3TRIM24 | |
| SCHEMBL15437321 | 0.80 | BRD4 (0.62) | BRD4CCL2KDM4ERAB9ABRD2 | |
| SCHEMBL15437234 | 0.78 | BRD4 (0.59) | BRD4CCL2BRD2BRD3TRIM24 | |
| SCHEMBL15437187 | 0.77 | BRD4 (0.60) | BRD4CCL2BRD2BRD3TRIM24 | |
| SCHEMBL15437553 | 0.77 | BRD4 (0.53) | BRD4CCL2BRD2BRD3TRIM24 | |
| SCHEMBL18871853 | 0.76 | BRD4 (0.48) | BRD4CCL2HRH3BRD2BRD3 | |
| SCHEMBL13723764 | 0.76 | BRD4 (0.48) | BRD4CCL2HRH3BRD2BRD3 | |
| SCHEMBL15437401 | 0.74 | BRD4 (0.60) | BRD4CCL2BRD2BRD3TRIM24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3168213-A1 | TETRAHYDROQUINOLINE DERIVATIVES USEFUL AS BROMODOMAIN INHIBITORS | Glaxosmithkline LLC (US) | 2017-05-17 | — | — | EP | disclosed |