Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 20/20 | 0.68 |
| ▸ | PSMB2 | P49721 | 18/20 | 0.68 |
| ▸ | PSMB1 | P20618 | 17/20 | 0.68 |
| ▸ | PSMB8 | P28062 | 16/20 | 0.68 |
| ▸ | PSMB9 | P28065 | 16/20 | 0.68 |
| ▸ | PSMB10 | P40306 | 16/20 | 0.68 |
| ▸ | PSMB11 | A5LHX3 | 15/20 | 0.68 |
| ▸ | PSMA7 | O14818 | 15/20 | 0.68 |
| ▸ | PSMA1 | P25786 | 15/20 | 0.68 |
| ▸ | PSMA2 | P25787 | 15/20 | 0.68 |
| ▸ | PSMA3 | P25788 | 15/20 | 0.68 |
| ▸ | PSMA4 | P25789 | 15/20 | 0.68 |
| ▸ | PSMA5 | P28066 | 15/20 | 0.68 |
| ▸ | PSMB4 | P28070 | 15/20 | 0.68 |
| ▸ | PSMB6 | P28072 | 15/20 | 0.68 |
| ▸ | PSMB3 | P49720 | 15/20 | 0.68 |
| ▸ | PSMA6 | P60900 | 15/20 | 0.68 |
| ▸ | PSMA8 | Q8TAA3 | 15/20 | 0.68 |
| ▸ | PSMB7 | Q99436 | 15/20 | 0.68 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1709160 | 1.00 | PSMB5 (0.68) | PSMB5PSMB2PSMB1PSMB8PSMB9 | |
| SCHEMBL2632873 | 1.00 | PSMB5 (0.68) | PSMB5PSMB2PSMB1PSMB8PSMB9 | |
| SCHEMBL2633227 | 0.94 | PSMB5 (0.69) | PSMB5PSMB2PSMB1PSMB8PSMB9 | |
| SCHEMBL84962 | 0.94 | PSMB5 (0.69) | PSMB5PSMB2PSMB1PSMB8PSMB9 | |
| SCHEMBL18875020 | 0.92 | PSMB5 (0.79) | PSMB5PSMB2PSMB1PSMB8PSMB9 | |
| SCHEMBL1709166 | 0.92 | PSMB5 (0.79) | PSMB5PSMB2PSMB1PSMB8PSMB9 | |
| SCHEMBL2632709 | 0.92 | PSMB5 (0.79) | PSMB5PSMB2PSMB1PSMB8PSMB9 | |
| SCHEMBL2633334 | 0.90 | PSMB5 (0.68) | PSMB5PSMB2PSMB1PSMB8PSMB9 | |
| SCHEMBL2633220 | 0.90 | PSMB5 (0.68) | PSMB5PSMB2PSMB1PSMB8PSMB9 | |
| SCHEMBL18871669 | 0.90 | PSMB5 (0.68) | PSMB5PSMB2PSMB1PSMB8PSMB9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9657058-B2 | Compounds for enzyme inhibition | ONYX THERAPEUTICS, INC. (US) | 2017-05-23 | — | — | US | disclosed |