Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 19/20 | 0.79 |
| ▸ | PSMB8 | P28062 | 17/20 | 0.79 |
| ▸ | PSMB2 | P49721 | 16/20 | 0.79 |
| ▸ | PSMB1 | P20618 | 15/20 | 0.79 |
| ▸ | PSMB9 | P28065 | 15/20 | 0.79 |
| ▸ | PSMB10 | P40306 | 14/20 | 0.79 |
| ▸ | PSMB11 | A5LHX3 | 13/20 | 0.79 |
| ▸ | PSMA7 | O14818 | 13/20 | 0.79 |
| ▸ | PSMA1 | P25786 | 13/20 | 0.79 |
| ▸ | PSMA2 | P25787 | 13/20 | 0.79 |
| ▸ | PSMA3 | P25788 | 13/20 | 0.79 |
| ▸ | PSMA4 | P25789 | 13/20 | 0.79 |
| ▸ | PSMA5 | P28066 | 13/20 | 0.79 |
| ▸ | PSMB4 | P28070 | 13/20 | 0.79 |
| ▸ | PSMB6 | P28072 | 13/20 | 0.79 |
| ▸ | PSMB3 | P49720 | 13/20 | 0.79 |
| ▸ | PSMA6 | P60900 | 13/20 | 0.79 |
| ▸ | PSMA8 | Q8TAA3 | 13/20 | 0.79 |
| ▸ | PSMB7 | Q99436 | 13/20 | 0.79 |
| ▸ | FPR2 | P25090 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18875020 | 1.00 | PSMB5 (0.79) | PSMB5PSMB8PSMB2PSMB1PSMB9 | |
| SCHEMBL2632709 | 1.00 | PSMB5 (0.79) | PSMB5PSMB8PSMB2PSMB1PSMB9 | |
| SCHEMBL2632873 | 0.92 | PSMB5 (0.68) | PSMB5PSMB8PSMB2PSMB1PSMB9 | |
| SCHEMBL1709160 | 0.92 | PSMB5 (0.68) | PSMB5PSMB8PSMB2PSMB1PSMB9 | |
| SCHEMBL18875019 | 0.92 | PSMB5 (0.68) | PSMB5PSMB8PSMB2PSMB1PSMB9 | |
| SCHEMBL2735637 | 0.91 | PSMB5 (0.77) | PSMB5PSMB8PSMB2PSMB1PSMB9 | |
| SCHEMBL1709172 | 0.91 | PSMB5 (0.77) | PSMB5PSMB8PSMB2PSMB1PSMB9 | |
| SCHEMBL18874968 | 0.91 | PSMB5 (0.77) | PSMB5PSMB8PSMB2PSMB1PSMB9 | |
| SCHEMBL20756646 | 0.87 | PSMB5 (0.77) | PSMB5PSMB8PSMB2PSMB1PSMB9 | |
| SCHEMBL16024787 | 0.87 | PSMB5 (0.77) | PSMB5PSMB8PSMB2PSMB1PSMB9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120088762-A1 | COMPOUNDS FOR ENZYME INHIBITION | ONYX THERAPEUTICS, INC. (US) | 2012-04-12 | — | — | US | disclosed |
| US-8080545-B2 | Compounds for enzyme inhibition | ONYX THERAPEUTICS, INC. (US) | 2011-12-20 | — | — | US | disclosed |
| US-20100144648-A1 | COMPOUNDS FOR ENZYME INHIBITION | ONYX THERAPEUTICS, INC. (US) | 2010-06-10 | — | — | US | disclosed |
| US-7691852-B2 | Compounds for enzyme inhibition | ONYX THERAPEUTICS, INC. (US) | 2010-04-06 | — | — | US | disclosed |
| US-20070293465-A1 | Compounds for enzyme inhibition | PROTEOLIX, INC. (US) | 2007-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088762-A1 | COMPOUNDS FOR ENZYME INHIBITION | PSME1, PSMB1, PSME3 | PSMB5 4/4885PSMB8 20/4885PSMB2 8/4885 |
| US-20070293465-A1 | Compounds for enzyme inhibition | PSME1, PSMB1, PSME3 | PSMB5 4/4885PSMB8 20/4885PSMB2 8/4885 |
| US-20100144648-A1 | COMPOUNDS FOR ENZYME INHIBITION | PSME1, PSMB1, PSME3 | PSMB5 4/4885PSMB8 20/4885PSMB2 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.