⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL459859 | 0.81 | — | — | |
| SCHEMBL5145331 | 0.79 | CA1 (0.41) | — | |
| SCHEMBL887259 | 0.79 | THRB (0.37) | — | |
| SCHEMBL5625359 | 0.79 | TSHR (0.44) | — | |
| SCHEMBL11663426 | 0.79 | TSHR (0.44) | — | |
| SCHEMBL27283702 | 0.79 | TSHR (0.44) | — | |
| SCHEMBL11416111 | 0.79 | TSHR (0.44) | — | |
| SCHEMBL9329861 | 0.77 | THRB (0.42) | — | |
| SCHEMBL9329817 | 0.77 | THRB (0.42) | — | |
| SCHEMBL9225312 | 0.77 | CA1 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7939510-B2 | Di(uridine 5′-)tetraphosphate and salts thereof | INSPIRE PHARMACEUTICALS, INC. (US) | 2011-05-10 | — | — | US | disclosed |
| US-20090326050-A1 | DI(URIDINE 5'-)TETRAPHOSPHATE AND SALTS THEREOF | MERCK SHARP & DOHME CORP. | 2009-12-31 | — | — | US | disclosed |
| US-7528119-B2 | Di(uridine 5′-)tetraphosphate and salts thereof | INSPIRE PHARMACEUTICALS, INC. (US) | 2009-05-05 | — | — | US | disclosed |
| US-20060258615-A1 | Di(uridine 5'-)tetraphosphate and salts thereof | MERCK SHARP & DOHME CORP. | 2006-11-16 | — | — | US | disclosed |
| US-7132410-B2 | Di(uridine 5′-)tetraphosphate and salts thereof | INSPIRE PHARMACEUTICALS, INC. (US) | 2006-11-07 | — | — | US | disclosed |
| US-7091334-B2 | Dissolving uridine nucleotide compound in a polar, aprotic organic solvent and a hydrophobic amine; activating, reacting with second uridine compound, purifying by chromatography | INSPIRE PHARMACEUTICALS, INC. (US) | 2006-08-15 | — | — | US | disclosed |
| US-20050148540-A1 | Di(uridine 5'-)tetraphosphate and salts thereof | MERCK SHARP & DOHME CORP. | 2005-07-07 | — | — | US | disclosed |
| US-6872710-B2 | Di(uridine 5′)-tetraphosphate and salts thereof | INSPIRE PHARMACEUTICALS, INC. (US) | 2005-03-29 | — | — | US | disclosed |
| US-20040267005-A1 | Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof | MERCK SHARP & DOHME CORP. | 2004-12-30 | — | — | US | disclosed |
| US-6765090-B2 | DRUGS; STABILITY, SOLUBILITY, NONTOXIC, EASY TO HANDLE | INSPIRE PHARMACEUTICALS, INC. | 2004-07-20 | — | — | US | disclosed |
| US-6713458-B1 | DRY EYE; RETINAL DETACHMENT | INSPIRE PHARMACEUTICALS, INC. | 2004-03-30 | — | — | US | disclosed |
| EP-1012154-B1 | SALTS OF DI(URIDINE 5'-TETRAPHOSPHATE), METHOD FOR PREPARATION AND USES THEREOF | INSPIRE PHARMACEUTICALS INC (US) | 2004-03-17 | — | — | EP | disclosed |
| US-20040014713-A1 | Di(uridine 5')-tetraphosphate and salts thereof | MERCK SHARP & DOHME CORP. | 2004-01-22 | — | — | US | disclosed |
| US-6548658-B2 | Tetrasodium, ammonium, lithium and potassium salts of P1, P4-di(uridine 5')-tetraphosphate; stable, soluble, nontoxic, of high purity and easy to handle during manufacture | INSPIRE PHARMACEUTICALS, INC. | 2003-04-15 | — | — | US | disclosed |
| US-20020086851-A1 | Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof | MERCK SHARP & DOHME CORP. | 2002-07-04 | — | — | US | disclosed |
| US-6319908-B1 | FOR THERAPY CYSTIC FIBROSIS, CHRONIC BRONCHITIS, ASTHMA, BRONCHIECTASIS, POST-OPERATIVE MUCOUS RETENTION, PNEUMONIA, PRIMARY CILIARY DYSKINESIA | INSPIRE PHARMACEUTICALS, INC. | 2001-11-20 | — | — | US | disclosed |
| US-20010011079-A1 | Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof | MERCK SHARP & DOHME CORP. | 2001-08-02 | — | — | US | disclosed |
| EP-1012154-A2 | SALTS OF DI(URIDINE 5'-TETRAPHOSPHATE), METHOD FOR PREPARATION AND USES THEREOF | Inspire Pharmaceuticals, Inc. (US) | 2000-06-28 | — | — | EP | disclosed |
| WO-1999005155-A2 | SALTS OF DI(URIDINE 5'-TETRAPHOSPHATE), METHOD FOR PREPARATION AND USES THEREOF | INSPIRE PHARMACEUTICALS, INC. (US) | 1999-02-04 | — | — | WO | disclosed |