⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL432519 | 0.76 | ALDH1A1 (0.36) | — | |
| SCHEMBL5552740 | 0.69 | — | — | |
| SCHEMBL686288 | 0.67 | — | — | |
| SCHEMBL127445 | 0.66 | — | — | |
| SCHEMBL16776 | 0.66 | — | — | |
| Hydrochloric Acid SCHEMBL3522396 | 0.64 | — | — | |
| SCHEMBL15740691 | 0.62 | — | — | |
| SCHEMBL11496537 | 0.60 | TSHR (0.43) | — | |
| Vinyl Ether SCHEMBL4482536 | 0.60 | TSHR (0.38) | — | |
| Vinyl Chloride SCHEMBL2557227 | 0.60 | TSHR (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947691-B2 | Cyclic n-hydroxy imides as inhibitors of flap endonuclease and uses thereof | ATHERSYS, INC. (US) | 2011-05-24 | — | — | US | disclosed |
| US-20080287465-A1 | Cyclic N-Hydroxy Imides as Inhibitors of Flap Endonuclease and Uses Thereof | ATHERSYS, INC. (US) | 2008-11-20 | — | — | US | disclosed |
| WO-2006014647-A2 | CYCLIC N-HYDROXY IMIDES AS INHIBITORS OF FLAP ENDONUCLEASE AND USES THEREOF | ATHERSYS, INC. (US) | 2006-02-09 | — | — | WO | disclosed |