Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12261608 | 0.78 | TDP1 (0.43) | TDP1ALOX5POLBMEN1CHRM2 | |
| SCHEMBL1579401 | 0.78 | TDP1 (0.43) | TDP1ALOX5POLBMEN1CHRM2 | |
| SCHEMBL2020599 | 0.78 | TDP1 (0.43) | TDP1ALOX5POLBMEN1CHRM2 | |
| SCHEMBL13226980 | 0.73 | TDP1 (0.48) | TDP1ALOX5POLBMEN1CHRM2 | |
| SCHEMBL20276748 | 0.73 | TDP1 (0.48) | TDP1ALOX5POLBMEN1CHRM2 | |
| SCHEMBL8228492 | 0.71 | TDP1 (0.46) | TDP1ALOX5POLBMEN1CHRM2 | |
| SCHEMBL12626512 | 0.71 | TDP1 (0.46) | TDP1ALOX5POLBMEN1CHRM2 | |
| SCHEMBL12625957 | 0.71 | TDP1 (0.46) | TDP1ALOX5POLBMEN1CHRM2 | |
| SCHEMBL18870054 | 0.71 | TDP1 (0.40) | TDP1ALOX5POLBMEN1CHRM2 | |
| SCHEMBL12261721 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108601766-B | CXCR2 inhibitors | 凯莫森特里克斯股份有限公司 | 2022-05-13 | — | — | CN | disclosed |
| US-20170144996-A1 | INHIBITORS OF CXCR2 | CHEMOCENTRYX, INC. | 2017-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170144996-A1 | INHIBITORS OF CXCR2 | CXCR2, CXCR3, CXCR1 | TDP1 4269/4885ALOX5 3187/4885POLB 3220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.