Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 14/20 | 0.47 |
| ▸ | GNRHR | P30968 | 1/20 | 0.43 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1884995 | 0.94 | GNRHR (0.45) | TRPM8GNRHRNR3C1 | |
| SCHEMBL1883637 | 0.91 | TRPM8 (0.51) | TRPM8SERPINE1NR3C1 | |
| SCHEMBL1883538 | 0.90 | CNR2 (0.47) | TRPM8GNRHR | |
| SCHEMBL1887957 | 0.90 | GNRHR (0.48) | TRPM8GNRHRNR3C1 | |
| SCHEMBL1885794 | 0.88 | TRPM8 (0.41) | TRPM8GNRHRNR3C1 | |
| SCHEMBL1891435 | 0.88 | GNRHR (0.42) | TRPM8GNRHR | |
| SCHEMBL1888276 | 0.87 | GNRHR (0.44) | TRPM8GNRHRNR3C1 | |
| SCHEMBL1890955 | 0.87 | TRPM8 (0.45) | TRPM8GNRHRHCRTR2 | |
| SCHEMBL1887547 | 0.86 | TRPM8 (0.44) | TRPM8GNRHR | |
| SCHEMBL1887598 | 0.86 | GNRHR (0.47) | TRPM8GNRHRNR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110105573-A1 | BENZIMIDAZOLE ACETIC ACIDS EXHIBITING CRTH2 RECEPTOR ANTAGONISM AND USES THEREOF | WYETH | 2011-05-05 | — | — | US | disclosed |
| US-7732618-B2 | Benzimidazole acetic acids exhibiting CRTH2 receptor antagonism and uses thereof | WYETH (US) | 2010-06-08 | — | — | US | disclosed |
| US-20060106081-A1 | Benzimidazole acetic acids exhibiting CRTH2 receptor antagonism and uses thereof | WYETH | 2006-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060106081-A1 | Benzimidazole acetic acids exhibiting CRTH2 receptor antagonism and uses thereof | HRH2, TBXA2R, PTGDR2 | TRPM8 771/4885GNRHR 742/4885SERPINE1 484/4885 |
| US-20110105573-A1 | BENZIMIDAZOLE ACETIC ACIDS EXHIBITING CRTH2 RECEPTOR ANTAGONISM AND USES THEREOF | HRH2, TBXA2R, PTGDR2 | TRPM8 771/4885GNRHR 742/4885SERPINE1 484/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.