Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 14/20 | 0.54 |
| ▸ | KDM5C | P41229 | 8/20 | 0.54 |
| ▸ | KDM5A | P29375 | 7/20 | 0.54 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.54 |
| ▸ | KDM5D | Q9BY66 | 1/20 | 0.54 |
| ▸ | KDM4A | O75164 | 2/20 | 0.53 |
| ▸ | KDM6B | O15054 | 1/20 | 0.53 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15994315 | 0.85 | KDM5B (0.75) | KDM5BKDM5CKDM5AKDM4CKDM5D | |
| SCHEMBL16293178 | 0.84 | KDM5B (0.74) | KDM5BKDM5CKDM5AKDM4CKDM5D | |
| SCHEMBL17364565 | 0.75 | KDM5B (0.75) | KDM5BKDM5CKDM5AKDM4CKDM5D | |
| SCHEMBL15994347 | 0.74 | KDM5B (0.73) | KDM5BKDM5CKDM5AKDM4CKDM5D | |
| SCHEMBL18880308 | 0.73 | KDM5B (0.74) | KDM5BKDM5CKDM5AKDM4CKDM5D | |
| SCHEMBL16006928 | 0.72 | CYP3A4 (0.43) | — | |
| SCHEMBL19574688 | 0.72 | KDM5B (0.69) | KDM5BKDM5CKDM5AKDM4CKDM5D | |
| SCHEMBL25380189 | 0.70 | KDM5B (1.00) | KDM5BKDM5CKDM5AKDM4CKDM5D | |
| SCHEMBL15636679 | 0.69 | KDM5B (1.00) | KDM5BKDM5CKDM5AKDM4CKDM5D | |
| SCHEMBL15994214 | 0.69 | KDM5B (0.72) | KDM5BKDM5CKDM5AKDM4CKDM5D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3170811-A1 | ETHYL PYRIDINE-4-CARBOXYLATE COMPOUND AS INHIBITOR OF HISTONE DEMETHYLASES | Gilead Sciences, Inc. (US) | 2017-05-24 | — | — | EP | disclosed |