Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 7/20 | 0.33 |
| ▸ | KDM5C | P41229 | 6/20 | 0.33 |
| ▸ | KDM4A | O75164 | 3/20 | 0.33 |
| ▸ | KDM4B | O94953 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 4/20 | 0.32 |
| ▸ | KDM6B | O15054 | 1/20 | 0.31 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.31 |
| ▸ | KDM5D | Q9BY66 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16292658 | 0.86 | KDM5B (0.40) | KDM5BKDM5CKDM4AKDM4BALDH1A1 | |
| SCHEMBL18880295 | 0.82 | KDM5B (0.51) | KDM5BKDM5CKDM4AKDM4BALDH1A1 | |
| SCHEMBL16293837 | 0.82 | KDM5B (0.37) | KDM5BKDM5CKDM4AKDM4BALDH1A1 | |
| SCHEMBL16293836 | 0.82 | KDM5B (0.37) | KDM5BKDM5CKDM4AKDM4BALDH1A1 | |
| SCHEMBL16305527 | 0.81 | S1PR1 (0.37) | KDM5BKDM5CKDM4AKDM5AKDM6B | |
| SCHEMBL16292953 | 0.81 | S1PR1 (0.37) | KDM5BKDM5CKDM4AKDM5AKDM6B | |
| SCHEMBL15996136 | 0.78 | KDM5B (0.62) | KDM5BKDM5CKDM4AKDM5AKDM6B | |
| SCHEMBL15996137 | 0.78 | KDM5B (0.62) | KDM5BKDM5CKDM4AKDM5AKDM6B | |
| SCHEMBL20042003 | 0.78 | KDM4A (0.33) | KDM5BKDM5CKDM4AKDM4BLMNA | |
| SCHEMBL16292659 | 0.78 | SIRT2 (0.34) | KDM5BKDM5CKDM4AKDM4BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3170811-A1 | ETHYL PYRIDINE-4-CARBOXYLATE COMPOUND AS INHIBITOR OF HISTONE DEMETHYLASES | Gilead Sciences, Inc. (US) | 2017-05-24 | — | — | EP | disclosed |