Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 2/20 | 0.33 |
| ▸ | KDM4B | O94953 | 2/20 | 0.33 |
| ▸ | KDM5C | P41229 | 2/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18880294 | 0.78 | KDM5B (0.33) | KDM4AKDM4BKDM5CKDM5BLMNA | |
| SCHEMBL16303330 | 0.78 | CHRM2 (0.35) | KDM4AKDM5CKDM5B | |
| SCHEMBL16292703 | 0.78 | CHRM2 (0.35) | KDM4AKDM5CKDM5B | |
| SCHEMBL16293836 | 0.77 | KDM5B (0.37) | KDM4AKDM4BKDM5CKDM5BLMNA | |
| SCHEMBL16293837 | 0.77 | KDM5B (0.37) | KDM4AKDM4BKDM5CKDM5BLMNA | |
| SCHEMBL15994272 | 0.76 | KDM5B (0.60) | KDM4AKDM5CKDM5B | |
| SCHEMBL16305526 | 0.76 | KDM5B (0.60) | KDM4AKDM5CKDM5B | |
| SCHEMBL16305531 | 0.74 | TERT (0.39) | KDM4AKDM5CKDM5BLMNA | |
| SCHEMBL16293473 | 0.74 | TERT (0.39) | KDM4AKDM5CKDM5BLMNA | |
| SCHEMBL16292658 | 0.73 | KDM5B (0.40) | KDM4AKDM4BKDM5CKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2961736-B1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES INC (US) | 2018-04-11 | — | — | EP | disclosed |