Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5C | P41229 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CCR4 | P51679 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18880300 | 0.84 | CHRM2 (0.42) | KDM5CKDM5BCHRM2SIRT2S1PR1 | |
| SCHEMBL15994510 | 0.82 | KDM5B (0.63) | KDM5CKDM5BCHRM2SIRT2S1PR1 | |
| SCHEMBL15994215 | 0.82 | CHRM2 (0.42) | KDM5CKDM5BCHRM2SIRT2S1PR1 | |
| SCHEMBL16293037 | 0.81 | CHRM2 (0.44) | KDM5CKDM5BCHRM2SIRT2S1PR1 | |
| SCHEMBL16292934 | 0.81 | CHRM2 (0.40) | KDM5CKDM5BCHRM2SIRT2S1PR1 | |
| SCHEMBL16292932 | 0.80 | S1PR1 (0.40) | KDM5CKDM5BCHRM2SIRT2S1PR1 | |
| SCHEMBL16293034 | 0.78 | CHRM2 (0.43) | KDM5CKDM5BCHRM2SIRT2S1PR1 | |
| SCHEMBL16293035 | 0.78 | CHRM2 (0.43) | KDM5CKDM5BCHRM2SIRT2S1PR1 | |
| SCHEMBL16006899 | 0.77 | KDM5B (0.45) | KDM5CKDM5BCHRM2CXCR4KDM4E | |
| SCHEMBL16303335 | 0.77 | CHRM2 (0.41) | KDM5CKDM5BCHRM2SIRT2S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3170811-A1 | ETHYL PYRIDINE-4-CARBOXYLATE COMPOUND AS INHIBITOR OF HISTONE DEMETHYLASES | Gilead Sciences, Inc. (US) | 2017-05-24 | — | — | EP | disclosed |