Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 15/20 | 0.75 |
| ▸ | PIK3CG | P48736 | 13/20 | 0.75 |
| ▸ | PI4KA | P42356 | 13/20 | 0.75 |
| ▸ | PI4KB | Q9UBF8 | 13/20 | 0.75 |
| ▸ | PIK3CD | O00329 | 12/20 | 0.75 |
| ▸ | PIK3CB | P42338 | 11/20 | 0.75 |
| ▸ | PIP5K1C | O60331 | 4/20 | 0.75 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.64 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.55 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3718112 | 0.86 | PIK3CA (0.70) | PIK3CAPIK3CGPI4KAPI4KBPIK3CD | |
| SCHEMBL3710766 | 0.85 | PIK3CA (0.68) | PIK3CAPIK3CGPI4KAPI4KBPIK3CD | |
| SCHEMBL17969354 | 0.85 | PIK3CG (0.63) | PIK3CAPIK3CGPI4KAPI4KBPIK3CD | |
| SCHEMBL13862776 | 0.84 | CYP3A4 (0.77) | PIK3CAPIK3CGPI4KAPI4KBPIK3CD | |
| SCHEMBL31114769 | 0.84 | CYP3A4 (0.77) | PIK3CAPIK3CGPI4KAPI4KBPIK3CD | |
| SCHEMBL12543471 | 0.82 | PI4KA (0.66) | PIK3CAPIK3CGPI4KAPI4KBPIK3CD | |
| SCHEMBL17969343 | 0.81 | PIK3CG (0.61) | PIK3CAPIK3CGPI4KAPI4KBPIK3CD | |
| SCHEMBL3708442 | 0.81 | PIK3CA (0.65) | PIK3CAPIK3CGPI4KAPI4KBPIK3CD | |
| SCHEMBL10081070 | 0.80 | PIK3CG (0.64) | PIK3CAPIK3CGPI4KAPI4KBPIK3CD | |
| SCHEMBL25303323 | 0.79 | PI4KA (0.72) | PIK3CAPIK3CGPI4KAPI4KBPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116143843-B | Metal complex with FTO inhibition activity and preparation method and application thereof | 南京师范大学 | 2024-12-20 | — | — | CN | disclosed |
| CN-116143843-A | Metal complex with FTO inhibition activity and preparation method and application thereof | 南京师范大学 | 2023-05-23 | — | — | CN | disclosed |
| US-8268999-B2 | Tri-cyclic pyrazolopyridine kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-09-18 | — | — | US | disclosed |
| US-8268999-B2 | Tri-cyclic pyrazolopyridine kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-09-18 | — | — | US | disclosed |
| US-8268999-B2 | Tri-cyclic pyrazolopyridine kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-09-18 | — | — | US | disclosed |
| US-20120053187-A1 | TRI-CYCLIC PYRAZOLOPYRIDINE KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-03-01 | — | — | US | disclosed |
| US-20120053187-A1 | TRI-CYCLIC PYRAZOLOPYRIDINE KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-03-01 | — | — | US | disclosed |
| US-20120053187-A1 | TRI-CYCLIC PYRAZOLOPYRIDINE KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-03-01 | — | — | US | disclosed |
| EP-2401273-A1 | TRI-CYCLIC PYRAZOLOPYRIDINE KINASE INHIBITORS | Vertex Pharmaceuticals Incorporated (US) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010135014-A1 | TRI-CYCLIC PYRAZOLOPYRIDINE KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-11-25 | — | — | WO | disclosed |
| WO-2010135014-A1 | TRI-CYCLIC PYRAZOLOPYRIDINE KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-11-25 | — | — | WO | disclosed |
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053187-A1 | TRI-CYCLIC PYRAZOLOPYRIDINE KINASE INHIBITORS | PIK3CA, PIK3CD, PIK3CG | PIK3CA 1/4885PIK3CG 3/4885PI4KA 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.