Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 16/20 | 0.70 |
| ▸ | PI4KA | P42356 | 16/20 | 0.70 |
| ▸ | PI4KB | Q9UBF8 | 16/20 | 0.70 |
| ▸ | PIK3CD | O00329 | 15/20 | 0.70 |
| ▸ | PIK3CG | P48736 | 14/20 | 0.70 |
| ▸ | PIK3CB | P42338 | 14/20 | 0.70 |
| ▸ | PIP5K1C | O60331 | 5/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.56 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.56 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.54 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3713650 | 0.89 | PIK3CG (0.62) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL3710766 | 0.87 | PIK3CA (0.68) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL188830 | 0.86 | PIK3CA (0.75) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL233589 | 0.82 | CYP3A4 (1.00) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL12543471 | 0.79 | PI4KA (0.66) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL3712055 | 0.78 | PIK3CG (0.84) | PIK3CAPIK3CGALDH1A1TP53HSD17B10 | |
| SCHEMBL13188383 | 0.78 | PIK3CG (1.00) | PIK3CAPIK3CGALDH1A1CYP3A4 | |
| SCHEMBL3708442 | 0.78 | PIK3CA (0.65) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL25644842 | 0.77 | PI4KA (0.73) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL31472553 | 0.77 | PI4KA (0.73) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |