Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 1/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | CNR2 | P34972 | 8/20 | 0.66 |
| ▸ | CNR1 | P21554 | 6/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | F7 | P08709 | 2/20 | 0.55 |
| ▸ | F3 | P13726 | 2/20 | 0.55 |
| ▸ | OXER1 | Q8TDS5 | 2/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.55 |
| ▸ | RXRA | P19793 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | PPARG | P37231 | 1/20 | 0.55 |
| ▸ | PPARD | Q03181 | 1/20 | 0.55 |
| ▸ | PPARA | Q07869 | 1/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.52 |
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12555962 | 0.93 | ALDH1A1 (0.81) | ALDH1A1KMT2AMEN1MAPTHPGD | |
| SCHEMBL15606927 | 0.87 | CNR2 (0.71) | ALDH1A1KMT2AMEN1MAPTHPGD | |
| SCHEMBL15526152 | 0.87 | CNR2 (0.71) | ALDH1A1KMT2AMEN1MAPTHPGD | |
| Clinolamide SCHEMBL2110787 | 0.86 | ALDH1A1 (0.80) | ALDH1A1KMT2AMEN1MAPTHPGD | |
| SCHEMBL22301830 | 0.83 | CNR2 (0.86) | ALDH1A1KMT2AMEN1MAPTHPGD | |
| SCHEMBL4982180 | 0.82 | MEN1 (1.00) | ALDH1A1KMT2AMEN1MAPTHPGD | |
| SCHEMBL4982184 | 0.82 | MEN1 (1.00) | ALDH1A1KMT2AMEN1MAPTHPGD | |
| SCHEMBL6517985 | 0.82 | MEN1 (1.00) | ALDH1A1KMT2AMEN1MAPTHPGD | |
| SCHEMBL12555840 | 0.82 | MEN1 (0.78) | ALDH1A1KMT2AMEN1MAPTHPGD | |
| SCHEMBL12555833 | 0.82 | ALDH1A1 (0.72) | ALDH1A1KMT2AMEN1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170144972-A1 | METHODS OF LOWERING PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) | CATABASIS PHARMACEUTICALS, INC. | 2017-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170144972-A1 | METHODS OF LOWERING PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) | PCSK9, PCSK6, PCSK7 | ALDH1A1 3440/4885KMT2A 2543/4885MEN1 1682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.