Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 20/20 | 0.71 |
| ▸ | PDE1A | P54750 | 2/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.52 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.52 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.52 |
| ▸ | PDE2A | O00408 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9910448 | 1.00 | MET (0.71) | METPDE1APDE4CPDE4DPDE3B | |
| SCHEMBL9910452 | 1.00 | MET (0.71) | METPDE1APDE4CPDE4DPDE3B | |
| SCHEMBL9910458 | 0.87 | MET (0.73) | METPDE1APDE4CPDE4DPDE3B | |
| SCHEMBL9910457 | 0.87 | MET (0.73) | METPDE1APDE4CPDE4DPDE3B | |
| SCHEMBL18885823 | 0.83 | MET (0.73) | METPDE1APDE4CPDE4DPDE3B | |
| SCHEMBL9910456 | 0.83 | MET (0.73) | METPDE1APDE4CPDE4DPDE3B | |
| SCHEMBL9910455 | 0.83 | MET (0.73) | METPDE1APDE4CPDE4DPDE3B | |
| SCHEMBL4143117 | 0.83 | MET (1.00) | METPDE1APDE4CPDE4DPDE3B | |
| SCHEMBL4143114 | 0.83 | MET (1.00) | METPDE1APDE4CPDE4DPDE3B | |
| SCHEMBL9910449 | 0.83 | MET (1.00) | METPDE1APDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3170824-A1 | 6-([1,2,4]TRIAZOLO[4,3-A]PYRIDIN-3-YLMETHYL)-1,6-NAPHTHYRIDIN-5(6H)-ONE DERIVATIVES AS C-MET INHIBITORS | Amgen, Inc (US) | 2017-05-24 | — | — | EP | disclosed |