Sugi Predict

Sugi Predict / Compounds / SCHEMBL1889132

SCHEMBL1889132

SCHEMBL1889132

CCOC(=O)n1nc(NC(=O)c2ccc(N3CCN(C)CC3)cc2N)c2c1CCN(S(=O)(=O)c1cccc(F)c1)C2

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 4/20 0.47
▸ HTT P42858 1/20 0.42
▸ INSR P06213 2/20 0.42
▸ ALK Q9UM73 2/20 0.42
▸ KMT2A Q03164 3/20 0.37
▸ POLB P06746 1/20 0.37
▸ GAA P10253 2/20 0.36
▸ MEN1 O00255 2/20 0.36
▸ HTR6 P50406 1/20 0.36
▸ BTK Q06187 2/20 0.36
▸ ALDH1A1 P00352 2/20 0.35
▸ TSHR P16473 1/20 0.35
▸ USP2 O75604 1/20 0.35
▸ MAPT P10636 1/20 0.35
▸ HPGD P15428 1/20 0.35
▸ NPSR1 Q6W5P4 1/20 0.35
▸ LMNA P02545 1/20 0.35
▸ FGFR4 P22455 1/20 0.35
▸ HDAC3 O15379 1/20 0.34
▸ HDAC8 Q9BY41 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL1889129 0.99 IGF1R (0.47) IGF1RHTTINSRALKKMT2A
SCHEMBL1887671 0.94 IGF1R (0.52) IGF1RHTTINSRALKBTK
Hydrochloric Acid SCHEMBL1887670 0.93 IGF1R (0.52) IGF1RHTTINSRALKBTK
SCHEMBL1894264 0.93 IGF1R (0.43) IGF1RHTTINSRALKKMT2A
SCHEMBL1891290 0.90 IGF1R (0.45) IGF1RHTTKMT2APOLBGAA
SCHEMBL1890393 0.89 IGF1R (0.42) IGF1RHTTINSRALKKMT2A
SCHEMBL4282875 0.87 IGF1R (0.45) IGF1RHTTINSRALKKMT2A
SCHEMBL1895721 0.86 IGF1R (0.45) IGF1RHTTINSRALKKMT2A
Hydrochloric Acid SCHEMBL1895719 0.86 IGF1R (0.45) IGF1RHTTINSRALKKMT2A
SCHEMBL1891244 0.85 IGF1R (0.43) IGF1RINSRALKKMT2APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8173659-B2 Substituted pyrazolo[4,3-C]pyridine derivatives active as kinase inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2012-05-08 — — US disclosed
US-20110230470-A1 SUBSTITUTED PYRAZOLO[4,3-C]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2011-09-22 — — US disclosed
US-7947686-B2 Substituted pyrazolo[4,3-c]pyridine derivatives active as kinase inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2011-05-24 — — US disclosed
US-20090023745-A1 Substituted Pyrazolo[4,3-c]Pyridine Derivatives Active as Kinase Inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2009-01-22 — — US disclosed
EP-1968976-A1 SUBSTITUTED PYRAZOLO [4,3-C] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.r.l. (IT) 2008-09-17 — — EP disclosed
WO-2007068619-A1 SUBSTITUTED PYRAZOLO [4,3-C] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2007-06-21 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110230470-A1 SUBSTITUTED PYRAZOLO[4,3-C]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS MAP3K3, MAP3K1, MAP3K19 IGF1R 760/4885HTT 4780/4885INSR 922/4885
US-20090023745-A1 Substituted Pyrazolo[4,3-c]Pyridine Derivatives Active as Kinase Inhibitors MAP3K3, MAP3K1, MAP3K19 IGF1R 760/4885HTT 4780/4885INSR 922/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.