Sugi Predict

Sugi Predict / Compounds / SCHEMBL1894264

SCHEMBL1894264

SCHEMBL1894264

CCOC(=O)n1nc(NC(=O)c2ccc(N3CCN(C)CC3)cc2N)c2c1CCN(S(=O)(=O)c1ccccc1)C2

nearest known ligand 0.43

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 3/20 0.43
▸ HTT P42858 1/20 0.43
▸ DRD3 P35462 5/20 0.40
▸ INSR P06213 1/20 0.39
▸ ALK Q9UM73 1/20 0.39
▸ HRH3 Q9Y5N1 1/20 0.39
▸ POLB P06746 1/20 0.38
▸ PTGDR Q13258 2/20 0.37
▸ HDAC3 O15379 1/20 0.37
▸ HDAC2 Q92769 1/20 0.37
▸ HTR6 P50406 3/20 0.37
▸ DRD2 P14416 1/20 0.36
▸ ATM Q13315 1/20 0.35
▸ MEN1 O00255 1/20 0.35
▸ KMT2A Q03164 1/20 0.35
▸ ALDH1A1 P00352 1/20 0.35
▸ LMNA P02545 1/20 0.35
▸ TMEM97 Q5BJF2 2/20 0.35
▸ SIGMAR1 Q99720 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1889132 0.93 IGF1R (0.47) IGF1RHTTINSRALKPOLB
Hydrochloric Acid SCHEMBL1889129 0.92 IGF1R (0.47) IGF1RHTTINSRALKPOLB
SCHEMBL1887671 0.92 IGF1R (0.52) IGF1RHTTINSRALKTMEM97
Hydrochloric Acid SCHEMBL1887670 0.91 IGF1R (0.52) IGF1RHTTINSRALKTMEM97
SCHEMBL1890393 0.90 IGF1R (0.42) IGF1RHTTINSRALKPOLB
SCHEMBL1890266 0.89 SIRT6 (0.42) IGF1RHTTPOLBPTGDRMEN1
SCHEMBL4283449 0.86 IGF1R (0.42) IGF1RHTTDRD3INSRALK
SCHEMBL1895721 0.84 IGF1R (0.45) IGF1RHTTINSRALKPOLB
Hydrochloric Acid SCHEMBL1895719 0.83 IGF1R (0.45) IGF1RHTTINSRALKPOLB
SCHEMBL4769107 0.83 IGF1R (0.56) IGF1RHTTINSRALKHDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8173659-B2 Substituted pyrazolo[4,3-C]pyridine derivatives active as kinase inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2012-05-08 — — US disclosed
US-20110230470-A1 SUBSTITUTED PYRAZOLO[4,3-C]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2011-09-22 — — US disclosed
US-7947686-B2 Substituted pyrazolo[4,3-c]pyridine derivatives active as kinase inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2011-05-24 — — US disclosed
US-20090023745-A1 Substituted Pyrazolo[4,3-c]Pyridine Derivatives Active as Kinase Inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2009-01-22 — — US disclosed
EP-1968976-A1 SUBSTITUTED PYRAZOLO [4,3-C] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.r.l. (IT) 2008-09-17 — — EP disclosed
WO-2007068619-A1 SUBSTITUTED PYRAZOLO [4,3-C] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2007-06-21 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110230470-A1 SUBSTITUTED PYRAZOLO[4,3-C]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS MAP3K3, MAP3K1, MAP3K19 IGF1R 760/4885HTT 4780/4885DRD3 4820/4885
US-20090023745-A1 Substituted Pyrazolo[4,3-c]Pyridine Derivatives Active as Kinase Inhibitors MAP3K3, MAP3K1, MAP3K19 IGF1R 760/4885HTT 4780/4885DRD3 4820/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.