Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | PIK3C3 | Q8NEB9 | 7/20 | 0.44 |
| ▸ | ATR | Q13535 | 7/20 | 0.43 |
| ▸ | MAP3K12 | Q12852 | 4/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18860561 | 0.87 | MAPK1 (0.51) | MAPK1PIK3C3ATRMTOR | |
| SCHEMBL18892042 | 0.79 | MAP4K1 (0.47) | MAPK1MAP3K12 | |
| SCHEMBL18860636 | 0.77 | MTOR (0.58) | ATRMTOR | |
| SCHEMBL21557641 | 0.75 | MAPK1 (0.48) | MAPK1MAP3K12 | |
| SCHEMBL18892245 | 0.75 | PIK3C3 (0.46) | PIK3C3ATRMTOR | |
| SCHEMBL21557693 | 0.73 | MAP3K12 (0.48) | MAPK1MAP3K12 | |
| SCHEMBL21557637 | 0.73 | MAP3K12 (0.48) | MAPK1MAP3K12 | |
| SCHEMBL18891655 | 0.73 | LRRK2 (0.47) | MAP3K12 | |
| SCHEMBL21557698 | 0.72 | MAPK1 (0.47) | MAPK1MAP3K12 | |
| SCHEMBL21557995 | 0.72 | MAPT (0.41) | MAPK1MAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3377491-B1 | AZAINDOLE DERIVATIVES AND THEIR USE AS ERK KINASE INHIBITORS | AGV DISCOVERY (FR) | 2019-11-13 | — | — | EP | disclosed |
| EP-3170822-A1 | AZAINDOLE DERIVATIVES AND THEIR USE AS ERK KINASE INHIBITORS | AGV Discovery (FR) | 2017-05-24 | — | — | EP | disclosed |