Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 12/20 | 0.46 |
| ▸ | MTOR | P42345 | 5/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | RICTOR | Q6R327 | 2/20 | 0.38 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.38 |
| ▸ | MAPKAP1 | Q9BPZ7 | 2/20 | 0.38 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18892244 | 0.87 | ATR (0.40) | PIK3C3MTORPIK3R1PIK3CAPDCD1 | |
| SCHEMBL18891809 | 0.80 | ACVR1 (0.42) | MTORPIK3R1PIK3CAMET | |
| SCHEMBL25970657 | 0.76 | PIK3C3 (0.43) | PIK3C3PDCD1CD274METATR | |
| SCHEMBL21557965 | 0.76 | ACVR1 (0.41) | PIK3CAMET | |
| SCHEMBL18892003 | 0.75 | MAPK1 (0.50) | PIK3C3MTORATR | |
| SCHEMBL21557690 | 0.74 | JAK2 (0.37) | PIK3C3MTORPIK3R1PIK3CARICTOR | |
| SCHEMBL21557648 | 0.74 | CHRNB2 (0.38) | — | |
| SCHEMBL21557989 | 0.74 | MET (0.37) | METATR | |
| SCHEMBL21557702 | 0.73 | MAP3K12 (0.38) | MTORPIK3CA | |
| SCHEMBL21557941 | 0.73 | PDE1B (0.42) | MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3377491-B1 | AZAINDOLE DERIVATIVES AND THEIR USE AS ERK KINASE INHIBITORS | AGV DISCOVERY (FR) | 2019-11-13 | — | — | EP | disclosed |
| EP-3170822-A1 | AZAINDOLE DERIVATIVES AND THEIR USE AS ERK KINASE INHIBITORS | AGV Discovery (FR) | 2017-05-24 | — | — | EP | disclosed |