Sugi Predict

Sugi Predict / Compounds / SCHEMBL188924

SCHEMBL188924

SCHEMBL188924

CC(C)N1CCN(c2ccc(N)cc2)CC1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 7/20 0.67
▸ ALDH1A1 P00352 5/20 0.67
▸ KDM4E B2RXH2 4/20 0.67
▸ PKM P14618 1/20 0.67
▸ GFER P55789 4/20 0.62
▸ GAA P10253 3/20 0.62
▸ KMT2A Q03164 2/20 0.62
▸ ADRA2C P18825 1/20 0.62
▸ PTK2B Q14289 1/20 0.62
▸ ESR2 Q92731 1/20 0.62
▸ LMNA P02545 3/20 0.57
▸ HTT P42858 2/20 0.57
▸ MAPK1 P28482 1/20 0.57
▸ TDP1 Q9NUW8 1/20 0.57
▸ SMN1; SMN2 Q16637 3/20 0.56
▸ RAD52 P43351 1/20 0.56
▸ L3MBTL1 Q9Y468 2/20 0.53
▸ MEN1 O00255 1/20 0.53
▸ NPC1 O15118 1/20 0.53
▸ USP2 O75604 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24618822 0.89 MAPT (0.60) MAPTALDH1A1KDM4EPKMGFER
SCHEMBL1127098 0.85 MAPT (0.58) MAPTALDH1A1KDM4EPKMGFER
SCHEMBL1813259 0.85 MAPT (0.58) MAPTALDH1A1KDM4EPKMGFER
SCHEMBL10169302 0.84 MAPT (0.67) MAPTALDH1A1KDM4EPKMGFER
SCHEMBL7043679 0.82 MAPT (0.77) MAPTALDH1A1KDM4EGFERGAA
SCHEMBL6151120 0.82 MAPT (0.77) MAPTALDH1A1KDM4EGFERGAA
SCHEMBL23347931 0.82 MAPT (0.77) MAPTALDH1A1KDM4EGFERGAA
SCHEMBL5744901 0.82 MAPT (0.59) MAPTALDH1A1KDM4EPKMGFER
SCHEMBL81911 0.82 MAPT (0.69) MAPTALDH1A1KDM4EPKMGAA
SCHEMBL20074141 0.82 KDM4E (0.69) MAPTALDH1A1KDM4EPKMGFER

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 331 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115108931-B Tofenamic acid derivative and preparation and application thereof 南华大学附属第一医院 2024-06-14 — — CN claimed
WO-2022233109-A1 RUBBER CONTAINING MODIFIED GRAPHENE 福建师范大学泉港石化研究院 2022-11-10 — — WO claimed
CN-113185759-B Rubber containing modified graphene 福建师范大学泉港石化研究院 2022-04-01 — — CN claimed
EP-2282995-B1 DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS NOVARTIS AG (CH) 2015-08-26 — — EP claimed
US-8536175-B2 Quinoxaline carboxamide derivatives as protein tyrosine kinase inhibitors NOVARTIS AG (CH) 2013-09-17 — — US claimed
US-7105670-B2 Intermediates useful in the preparation of diaminothiazoles HOFFMANN-LA ROCHE INC. (US) 2006-09-12 — — US claimed
EP-1358169-B1 DIAMINOTHIAZOLES AND THEIR USE AS INHIBITORS OF CYCLIN-DEPENDENT KINASE HOFFMANN LA ROCHE (CH) 2006-01-11 — — EP claimed
US-20040082595-A1 Intermediates useful in the preparation of diaminothiazoles DING QINGJIE (US) 2004-04-29 — — US claimed
EP-1383753-A1 PIPERAZINE-BENZAMIDE DERIVATIVES USEFUL AS APOB-100 AND/OR MTP INHIBITOR GLAXO GROUP LIMITED (GB) 2004-01-28 — — EP claimed
EP-1358169-A2 DIAMINOTHIAZOLES AND THEIR USE AS INHIBITORS OF CYCLIN-DEPENDENT KINASE F. HOFFMANN-LA ROCHE AG (CH) 2003-11-05 — — EP claimed
WO-2003047575-A1 THERAPEUTIC BENZAMIDE DERIVATIVES GLAXO GROUP LIMITED (GB) 2003-06-12 — — WO claimed
WO-2003048121-A1 THERAPEUTIC BENZAMIDE DERIVATIVES GLAXO GROUP LIMITED (GB) 2003-06-12 — — WO claimed
WO-2002083658-A1 PIPERAZINE-BENZAMIDE DERIVATIVES USEFUL AS APOB-100 AND/OR MTP INHIBITOR GLAXO GROUP LIMITED (GB) 2002-10-24 — — WO claimed
US-20020151554-A1 Diaminothiazoles having antiproliferative activity CHEN LI (US) 2002-10-17 — — US claimed
WO-2002057261-A2 DIAMINOTHIAZOLES AND THEIR USE AS INHIBITORS OF CYCLIN-DEPENDENT KINASE F. HOFFMANN-LA ROCHE AG (CH) 2002-07-25 — — WO claimed
US-20260137703-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER CANCER RESEARCH TECH LIMITED (GB) 2026-05-21 — — US disclosed
EP-4615824-A1 SUBSTITUTED QUINOLONE COMPOUNDS USEFUL AS INHIBITORS OF TLR9 Bristol-Myers Squibb Company (US) 2025-09-17 — — EP disclosed
WO-2002083658-A1 PIPERAZINE-BENZAMIDE DERIVATIVES USEFUL AS APOB-100 AND/OR MTP INHIBITOR GLAXO GROUP LIMITED (GB) 2002-10-24 — — WO disclosed
US-20020151554-A1 Diaminothiazoles having antiproliferative activity CHEN LI (US) 2002-10-17 — — US disclosed
WO-2002057261-A2 DIAMINOTHIAZOLES AND THEIR USE AS INHIBITORS OF CYCLIN-DEPENDENT KINASE F. HOFFMANN-LA ROCHE AG (CH) 2002-07-25 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260137703-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER EGFR, KRAS, O60361 MAPT 4708/4885ALDH1A1 999/4885KDM4E 4425/4885
US-20020151554-A1 Diaminothiazoles having antiproliferative activity CDK4, CDK2, CDKL4 MAPT 3064/4885ALDH1A1 1009/4885KDM4E 973/4885
US-20040082595-A1 Intermediates useful in the preparation of diaminothiazoles CDK4, CDK2, CDKL4 MAPT 2939/4885ALDH1A1 858/4885KDM4E 1021/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.