SCHEMBL30227352

SCHEMBL30227352

Cc1nc(NC(=O)n2ccnc2)sc1-c1ccnc(C(C)(C)C(F)(F)F)c1

nearest known ligand 0.63

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PIK3CA P42336 19/20 0.63
PIK3CD O00329 9/20 0.62
PIK3CG P48736 8/20 0.62
PIK3CB P42338 7/20 0.62
GAK O14976 1/20 0.62
PRKACG P22612 1/20 0.62
PIK3R1 P27986 1/20 0.62
MTOR P42345 1/20 0.62
PI4KB Q9UBF8 1/20 0.62
HDAC6 Q9UBN7 10/20 0.54
HDAC1 Q13547 1/20 0.50
HDAC11 Q96DB2 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15803547 1.00 PIK3CA (0.63) PIK3CAPIK3CDPIK3CGPIK3CBGAK
SCHEMBL571452 0.91 PIK3CA (0.69) PIK3CAPIK3CDPIK3CGPIK3CBGAK
SCHEMBL24023242 0.86 PIK3CA (0.56) PIK3CAPIK3CDPIK3CGPIK3CBGAK
SCHEMBL28970637 0.85 PIK3CA (0.53) PIK3CAPIK3CDPIK3CGPIK3CBGAK
SCHEMBL24023232 0.84 PIK3CA (0.54) PIK3CAPIK3CDPIK3CGPIK3CBGAK
SCHEMBL15803671 0.83 PIK3CA (0.64) PIK3CAPIK3CDPIK3CGPIK3CBGAK
SCHEMBL19751590 0.83 PIK3CA (0.82) PIK3CAPIK3CDPIK3CGPIK3CBGAK
SCHEMBL1889405 0.82 PIK3CA (0.50) PIK3CAPIK3CDPIK3CGPIK3CBGAK
SCHEMBL1939665 0.82 PIK3CA (0.52) PIK3CAPIK3CDPIK3CGPIK3CBGAK
SCHEMBL24023246 0.81 PIK3CA (0.48) PIK3CAPIK3CDPIK3CGPIK3CBGAK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4608509-A1 NEW INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE Institut National de la Santé et de la Recherche Médicale (FR) 2025-09-03 EP disclosed
WO-2024089272-A1 NEW INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) 2024-05-02 WO disclosed
EP-4126815-A1 STABLE HEAVY ISOTOPES IN AMIDE FUNCTIONAL GROUPS AND USES THEREOF Risen (Suzhou) Pharma Tech Co., Ltd. (CN) 2023-02-08 EP disclosed