Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 5/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 5/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydantoin SCHEMBL27574136 | 0.82 | CRBN (0.46) | HDAC8DDB1CRBNHPGD | |
| Hydantoin SCHEMBL27362965 | 0.81 | TDP1 (0.44) | HDAC8DDB1CRBNHPGDMEN1 | |
| Biphenyl SCHEMBL1712625 | 0.80 | TYRO3 (0.42) | HDAC8GSK3AGSK3BCRBNHPGD | |
| Hydantoin SCHEMBL10500940 | 0.79 | HDAC8 (0.38) | HDAC8GSK3AGSK3BDDB1CRBN | |
| Biphenyl SCHEMBL9013643 | 0.79 | TYRO3 (0.41) | HDAC8GSK3AGSK3BCRBNHPGD | |
| Dl-Phenylalanine SCHEMBL6666683 | 0.78 | SLC7A5 (0.63) | HDAC8LTA4H | |
| D-Phenylalanine SCHEMBL1033916 | 0.78 | SLC7A5 (0.63) | HDAC8LTA4H | |
| Phenylalanine SCHEMBL1033179 | 0.78 | SLC7A5 (0.63) | HDAC8LTA4H | |
| Hydantoin SCHEMBL599570 | 0.78 | CRBN (0.42) | CRBNKMT2A | |
| Biphenyl SCHEMBL9013682 | 0.77 | TYRO3 (0.40) | HDAC8GSK3AGSK3BCRBNHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017091168-A1 | A TOPICAL SPRAY COMPRISING ISOCONAZOLE NITRATE AND DIFLUOCORTOLONE VALERATE | PHARMACTİVE İLAÇ SAN. VE TİC. A.Ş. (TR) | 2017-06-01 | — | — | WO | disclosed |