Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.31 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22819234 | 0.73 | MAPT (0.42) | MAPT | |
| SCHEMBL18165594 | 0.72 | MAPT (0.51) | MAPT | |
| SCHEMBL18165570 | 0.72 | MAPT (0.51) | MAPT | |
| SCHEMBL18165565 | 0.72 | MAPT (0.51) | MAPT | |
| SCHEMBL1783386 | 0.72 | MAPT (0.56) | MAPT | |
| SCHEMBL18165567 | 0.72 | MAPT (0.51) | MAPT | |
| SCHEMBL17085339 | 0.72 | MAPT (0.51) | MAPT | |
| SCHEMBL26550965 | 0.70 | MAPT (0.50) | MAPT | |
| SCHEMBL18736437 | 0.70 | — | — | |
| SCHEMBL12927382 | 0.69 | MAPT (0.49) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3380471-A1 | COMT INHIBITING METHODS AND COMPOSITIONS | Lieber Institute For Brain Development (US) | 2018-10-03 | — | — | EP | disclosed |
| WO-2017091818-A1 | COMT INHIBITING METHODS AND COMPOSITIONS | LIEBER INSTITUTE FOR BRAIN DEVELOPMENT (US) | 2017-06-01 | — | — | WO | disclosed |