Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453964 | 0.83 | FAAH (0.35) | EPHX2PPARAELANE | |
| SCHEMBL13450366 | 0.77 | CCNB2 (0.33) | — | |
| SCHEMBL5536581 | 0.77 | MAPT (0.37) | MAPTKCNH2TLR7KDM4EMEN1 | |
| SCHEMBL1520366 | 0.77 | TDP1 (0.34) | MAPTKCNH2TLR7KDM4EMEN1 | |
| SCHEMBL5536577 | 0.75 | MAPT (0.36) | MAPTKCNH2TLR7KDM4EMEN1 | |
| SCHEMBL5538019 | 0.74 | TDP1 (0.35) | MAPTKCNH2TLR7KDM4EMEN1 | |
| SCHEMBL2062290 | 0.74 | PPARA (0.36) | MAPTKCNH2TLR7KDM4EMEN1 | |
| SCHEMBL5538016 | 0.73 | TDP1 (0.34) | MAPTKCNH2TLR7KDM4EMEN1 | |
| SCHEMBL3733911 | 0.73 | SIRT2 (0.37) | MAPTKCNH2TLR7EPHX2 | |
| SCHEMBL4560384 | 0.73 | TLR7 (0.44) | MAPTTLR7KDM4EMEN1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9663466-B2 | Aryl dihydropyridinones and piperidinone MGAT2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-05-30 | — | — | US | disclosed |
| US-9663466-B2 | Aryl dihydropyridinones and piperidinone MGAT2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-05-30 | — | — | US | disclosed |