Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.43 |
| ▸ | LTA4H | P09960 | 2/20 | 0.34 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 3/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15478375 | 0.93 | CCR1 (0.50) | CCR1HRH1OPRL1SIGMAR1OPRM1 | |
| SCHEMBL18633827 | 0.87 | CCR1 (0.39) | CCR1HRH1SIGMAR1MEN1KMT2A | |
| SCHEMBL15478333 | 0.82 | DRD2 (0.40) | CCR1OPRL1OPRM1DRD2 | |
| SCHEMBL10287677 | 0.81 | CCR1 (0.42) | CCR1 | |
| SCHEMBL15478355 | 0.81 | CCR1 (0.38) | CCR1OPRL1SIGMAR1OPRM1DRD2 | |
| SCHEMBL15478359 | 0.81 | CCR1 (0.38) | CCR1HRH1OPRL1OPRM1DRD2 | |
| SCHEMBL15478420 | 0.80 | CCR1 (0.37) | CCR1HRH1DRD2 | |
| SCHEMBL14419960 | 0.80 | DRD2 (0.37) | CCR1HRH1OPRL1SIGMAR1OPRM1 | |
| SCHEMBL15478401 | 0.79 | CCR1 (0.37) | CCR1HRH1OPRL1SIGMAR1OPRM1 | |
| SCHEMBL13824505 | 0.79 | CCR1 (0.32) | CCR1HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9663537-B2 | Chemokine receptor antagonists and methods of use | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2017-05-30 | — | — | US | disclosed |