Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 3/20 | 0.39 |
| ▸ | HRH1 | P35367 | 4/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL652907 | 0.86 | CCR1 (0.56) | CCR1CHRM2CCR5HTR2BHRH1 | |
| SCHEMBL652906 | 0.86 | CCR1 (0.56) | CCR1CHRM2CCR5HTR2BHRH1 | |
| SCHEMBL10288001 | 0.86 | CCR1 (0.56) | CCR1CHRM2CCR5HTR2BHRH1 | |
| SCHEMBL18896076 | 0.76 | CCR1 (0.53) | CCR1CHRM2CCR5 | |
| SCHEMBL12936663 | 0.74 | CCR1 (0.56) | CCR1CHRM2CCR5HTR2BHRH1 | |
| SCHEMBL656469 | 0.73 | CCR1 (0.65) | CCR1CHRM2CCR5HTR2BHRH1 | |
| SCHEMBL656470 | 0.73 | CCR1 (0.65) | CCR1CHRM2CCR5HTR2BHRH1 | |
| SCHEMBL14419998 | 0.72 | CCR1 (0.54) | CCR1CHRM2CCR5HTR2BHRH1 | |
| SCHEMBL656143 | 0.72 | CCR1 (0.63) | CCR1CHRM2CCR5HTR2BHRH1 | |
| SCHEMBL656144 | 0.72 | CCR1 (0.63) | CCR1CHRM2CCR5HTR2BHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9663537-B2 | Chemokine receptor antagonists and methods of use | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2017-05-30 | — | — | US | disclosed |