Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13592766 | 0.85 | ALDH1A1 (0.54) | ALDH1A1MEN1KMT2ATDP1TSHR | |
| SCHEMBL18895835 | 0.85 | MEN1 (0.51) | ALDH1A1MEN1KMT2ATDP1MAOB | |
| SCHEMBL10084047 | 0.83 | ALDH1A1 (0.61) | ALDH1A1MEN1KMT2ATDP1TSHR | |
| SCHEMBL18710598 | 0.81 | ALDH1A1 (0.54) | ALDH1A1MEN1KMT2ATDP1TSHR | |
| SCHEMBL18896152 | 0.80 | MEN1 (0.50) | ALDH1A1MEN1KMT2ATDP1MAOB | |
| SCHEMBL13592748 | 0.80 | ALDH1A1 (0.55) | ALDH1A1MEN1KMT2ATDP1TSHR | |
| SCHEMBL12040277 | 0.80 | MEN1 (0.49) | ALDH1A1MEN1KMT2ATDP1TSHR | |
| SCHEMBL3434771 | 0.80 | ALDH1A1 (0.58) | ALDH1A1MEN1KMT2ATDP1TSHR | |
| SCHEMBL18713539 | 0.79 | ALDH1A1 (0.61) | ALDH1A1MEN1KMT2ATDP1TSHR | |
| SCHEMBL18896126 | 0.79 | MEN1 (0.49) | ALDH1A1MEN1KMT2ATDP1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9663466-B2 | Aryl dihydropyridinones and piperidinone MGAT2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-05-30 | — | — | US | disclosed |