Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.37 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22856971 | 0.83 | PRSS1 (0.40) | TSHRTAAR1CSNK1ECNR2RECQL | |
| SCHEMBL22604243 | 0.81 | PRSS1 (0.39) | TSHRTAAR1CSNK1ECNR2RECQL | |
| SCHEMBL28157803 | 0.81 | BDKRB2 (0.38) | TSHRCSNK1ECNR2LIPGCYP1A2 | |
| SCHEMBL26049936 | 0.80 | TSHR (0.41) | TSHRTAAR1IDO1CYP1A2CYP2D6 | |
| SCHEMBL6015484 | 0.79 | TSHR (0.45) | TSHRCSNK1ELIPGCYP2D6 | |
| SCHEMBL27813179 | 0.78 | TSHR (0.44) | TSHRCSNK1ELIPGMEN1KMT2A | |
| SCHEMBL27980703 | 0.78 | TSHR (0.44) | TSHRCSNK1ELIPGMEN1KMT2A | |
| SCHEMBL27833253 | 0.78 | TSHR (0.44) | TSHRCSNK1ELIPGMEN1KMT2A | |
| SCHEMBL27833312 | 0.78 | TSHR (0.44) | TSHRCSNK1ELIPGMEN1KMT2A | |
| SCHEMBL27813184 | 0.78 | TSHR (0.44) | TSHRCSNK1ELIPGMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9662335-B2 | Heteroaryl substituted pyrrolo[2,3-B] pyridines and pyrrolo[2,3-B] pyrimidines as janus kinase inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2017-05-30 | — | — | US | disclosed |