Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | CNR2 | P34972 | 2/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6793349 | 0.80 | MEN1 (0.59) | KMT2AMEN1HDAC8HDAC6EPHX2 | |
| SCHEMBL28005485 | 0.77 | MEN1 (0.55) | KMT2AMEN1HDAC8HDAC6EPHX2 | |
| SCHEMBL15338469 | 0.77 | MEN1 (0.65) | KMT2AMEN1HDAC8HDAC6EPHX2 | |
| SCHEMBL699925 | 0.76 | MEN1 (0.71) | KMT2AMEN1HDAC8HDAC6EPHX2 | |
| SCHEMBL7107935 | 0.76 | ALDH1A1 (0.77) | KMT2AMEN1HDAC8HDAC6EPHX2 | |
| SCHEMBL29156061 | 0.76 | MEN1 (0.53) | KMT2AMEN1HDAC8HDAC6EPHX2 | |
| SCHEMBL13946104 | 0.74 | MEN1 (0.52) | KMT2AMEN1HDAC8HDAC6EPHX2 | |
| Phenylacetohydroxamic Acid SCHEMBL213873 | 0.74 | HDAC8 (1.00) | KMT2AMEN1HDAC8HDAC6EPHX2 | |
| SCHEMBL13947167 | 0.73 | MEN1 (0.50) | KMT2AMEN1HDAC8HDAC6EPHX2 | |
| SCHEMBL11242611 | 0.72 | MEN1 (0.65) | KMT2AMEN1HDAC8HDAC6EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9662335-B2 | Heteroaryl substituted pyrrolo[2,3-B] pyridines and pyrrolo[2,3-B] pyrimidines as janus kinase inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2017-05-30 | — | — | US | disclosed |