Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.45 |
| ▸ | IDH1 | O75874 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12251287 | 0.86 | KMT2A (0.51) | KMT2AMEN1ALDH1A1CYP19A1IDH1 | |
| SCHEMBL14518240 | 0.86 | KMT2A (0.51) | KMT2AMEN1ALDH1A1CYP19A1IDH1 | |
| SCHEMBL22604271 | 0.82 | KMT2A (0.43) | KMT2AMEN1ALDH1A1CYP19A1IDH1 | |
| SCHEMBL20963179 | 0.80 | CYP19A1 (0.49) | KMT2AMEN1ALDH1A1CYP19A1IDH1 | |
| SCHEMBL12309934 | 0.80 | KMT2A (0.54) | KMT2AMEN1ALDH1A1CYP19A1IDH1 | |
| SCHEMBL11001193 | 0.79 | CYP19A1 (0.56) | KMT2AMEN1ALDH1A1CYP19A1LMNA | |
| SCHEMBL10959984 | 0.77 | CYP19A1 (0.56) | KMT2AMEN1ALDH1A1CYP19A1IDH1 | |
| SCHEMBL10832172 | 0.76 | KMT2A (0.32) | KMT2AMEN1ALDH1A1CYP19A1 | |
| SCHEMBL12462114 | 0.74 | CYP19A1 (0.53) | KMT2AMEN1ALDH1A1CYP19A1LMNA | |
| SCHEMBL7783933 | 0.73 | TSHR (0.58) | KMT2AMEN1ALDH1A1CYP19A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9662335-B2 | Heteroaryl substituted pyrrolo[2,3-B] pyridines and pyrrolo[2,3-B] pyrimidines as janus kinase inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2017-05-30 | — | — | US | disclosed |