Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1B2 | O75343 | 3/20 | 0.37 |
| ▸ | GUCY1A2 | P33402 | 3/20 | 0.37 |
| ▸ | GUCY1A1 | Q02108 | 3/20 | 0.37 |
| ▸ | GUCY1B1 | Q02153 | 3/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18899190 | 0.66 | GUCY1B2 (0.41) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1HDAC3 | |
| SCHEMBL18899080 | 0.65 | GUCY1B2 (0.46) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1OPRK1 | |
| SCHEMBL20309934 | 0.64 | GUCY1B2 (0.48) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1OPRK1 | |
| SCHEMBL20309818 | 0.64 | GUCY1B2 (0.65) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1OPRK1 | |
| SCHEMBL15075439 | 0.63 | SMN1; SMN2 (0.40) | SMN1; SMN2ADORA2AMEN1GALR3GAA | |
| SCHEMBL10330275 | 0.62 | KDM4E (0.49) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL29007620 | 0.62 | SMN1; SMN2 (0.62) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL15075433 | 0.61 | ADORA2A (0.40) | SMN1; SMN2ADORA2AMEN1GALR3GAA | |
| SCHEMBL17481626 | 0.61 | GUCY1B2 (0.80) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1OPRK1 | |
| SCHEMBL23434369 | 0.60 | GUCY1B2 (0.52) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3173407-A1 | SGC STIMULATORS | Ironwood Pharmaceuticals, Inc. (US) | 2017-05-31 | — | — | EP | disclosed |