Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1B2 | O75343 | 19/20 | 0.46 |
| ▸ | GUCY1A2 | P33402 | 19/20 | 0.46 |
| ▸ | GUCY1A1 | Q02108 | 19/20 | 0.46 |
| ▸ | GUCY1B1 | Q02153 | 19/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18405090 | 0.81 | GUCY1B2 (0.43) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1OPRK1 | |
| SCHEMBL18899190 | 0.79 | GUCY1B2 (0.41) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1OPRK1 | |
| SCHEMBL10269525 | 0.77 | GUCY1B2 (0.78) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1OPRK1 | |
| SCHEMBL18899030 | 0.76 | GUCY1B2 (0.44) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1OPRK1 | |
| SCHEMBL23064035 | 0.75 | ALDH1A1 (0.49) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1OPRK1 | |
| SCHEMBL18405059 | 0.74 | GUCY1B2 (0.46) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1OPRK1 | |
| SCHEMBL6214026 | 0.72 | BUB1 (0.53) | — | |
| SCHEMBL974087 | 0.70 | ADORA3 (0.56) | GUCY1A1GUCY1B1 | |
| SCHEMBL29378676 | 0.70 | ADORA3 (0.56) | GUCY1A1GUCY1B1 | |
| SCHEMBL30298890 | 0.70 | ADORA3 (0.56) | GUCY1A1GUCY1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3173407-A1 | SGC STIMULATORS | Ironwood Pharmaceuticals, Inc. (US) | 2017-05-31 | — | — | EP | disclosed |