SCHEMBL18900577

SCHEMBL18900577

CN(Cl)[C@@H]1C[C@H](CO)[C@@H](OC(=O)c2ccccc2)[C@H]1OC(=O)c1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 3/20 0.41
LGALS9 O00182 1/20 0.40
LGALS1 P09382 1/20 0.40
LGALS3 P17931 1/20 0.40
LGALS7; LGALS7B P47929 1/20 0.40
HTR3E A5X5Y0 2/20 0.39
HTR3B O95264 2/20 0.39
HTR3A P46098 2/20 0.39
HTR3D Q70Z44 2/20 0.39
HTR3C Q8WXA8 2/20 0.39
APOBEC3A P31941 1/20 0.39
APOBEC3G Q9HC16 1/20 0.39
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
GAA P10253 1/20 0.37
CES2 O00748 1/20 0.37
CYP1A2 P05177 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C19 P33261 1/20 0.36
CHRM2 P08172 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15095818 0.80 LGALS9 (0.44) CHRNA7LGALS9LGALS1LGALS3LGALS7; LGALS7B
SCHEMBL15215807 0.77 LGALS9 (0.44) CHRNA7LGALS9LGALS1LGALS3LGALS7; LGALS7B
SCHEMBL12070275 0.77 LGALS9 (0.44) CHRNA7LGALS9LGALS1LGALS3LGALS7; LGALS7B
SCHEMBL15215757 0.77 LGALS9 (0.44) CHRNA7LGALS9LGALS1LGALS3LGALS7; LGALS7B
SCHEMBL12392953 0.77 LGALS9 (0.44) CHRNA7LGALS9LGALS1LGALS3LGALS7; LGALS7B
SCHEMBL18896495 0.76 LGALS9 (0.41) CHRNA7LGALS9LGALS1LGALS3LGALS7; LGALS7B
Hydrochloric Acid SCHEMBL782523 0.76 LGALS9 (0.43) CHRNA7LGALS9LGALS1LGALS3LGALS7; LGALS7B
SCHEMBL12392959 0.74 SMN1; SMN2 (0.43) CHRNA7LGALS9LGALS1LGALS3LGALS7; LGALS7B
SCHEMBL12069028 0.72 LGALS9 (0.45) CHRNA7LGALS9LGALS1LGALS3LGALS7; LGALS7B
SCHEMBL15215812 0.72 LGALS9 (0.45) CHRNA7LGALS9LGALS1LGALS3LGALS7; LGALS7B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3536692-B1 PYRAZOLOPYRIMIDINYL INHIBITORS OF UBIQUITIN-ACTIVATING ENZYME MILLENNIUM PHARM INC (US) 2021-04-07 EP disclosed
EP-3536692-A1 PYRAZOLOPYRIMIDINYL INHIBITORS OF UBIQUITIN-ACTIVATING ENZYME Millennium Pharmaceuticals, Inc. (US) 2019-09-11 EP disclosed
EP-3173413-A1 PYRAZOLOPYRIMIDINYL INHIBITORS OF UBIQUITIN-ACTIVATING ENZYME Millennium Pharmaceuticals, Inc. (US) 2017-05-31 EP disclosed