Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.54 |
| ▸ | F10 | P00742 | 3/20 | 0.54 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.54 |
| ▸ | CFD | P00746 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17790218 | 0.83 | ROCK2 (0.55) | MEN1KMT2AHDAC6HDAC3HDAC4 | |
| SCHEMBL18175993 | 0.82 | MEN1 (0.59) | MEN1KMT2AHDAC6HDAC3HDAC4 | |
| SCHEMBL28871861 | 0.82 | F10 (0.60) | MEN1KMT2AHDAC6HDAC3HDAC4 | |
| SCHEMBL28316681 | 0.81 | F10 (0.53) | F10PRSS1CFDLOXL2MAPK14 | |
| SCHEMBL18901389 | 0.80 | HPGD (0.70) | MEN1KMT2APOLBROCK2 | |
| SCHEMBL19954249 | 0.80 | MEN1 (0.54) | MEN1KMT2AHDAC6HDAC3HDAC4 | |
| SCHEMBL7262357 | 0.79 | MEN1 (0.57) | MEN1KMT2AHDAC6HDAC3HDAC4 | |
| SCHEMBL8297087 | 0.79 | HPGD (0.65) | MEN1KMT2AHDAC6HDAC8POLB | |
| SCHEMBL29032735 | 0.79 | MEN1 (0.86) | MEN1KMT2AHDAC6HDAC3HDAC4 | |
| SCHEMBL3246370 | 0.79 | MEN1 (0.59) | MEN1KMT2AHDAC6HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3016951-B1 | TRICYCLIC PYRIDO-CARBOXAMIDE DERIVATIVES AS ROCK INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-05-31 | — | — | EP | disclosed |