Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 20/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17783501 | 0.87 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL16345037 | 0.87 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL17783368 | 0.79 | ROCK2 (0.85) | ROCK2 | |
| SCHEMBL18901199 | 0.79 | ROCK2 (0.69) | ROCK2 | |
| SCHEMBL17788682 | 0.78 | ROCK2 (0.83) | ROCK2 | |
| SCHEMBL17783463 | 0.78 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL18901341 | 0.78 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL16345038 | 0.77 | ROCK2 (0.67) | ROCK2 | |
| SCHEMBL17783498 | 0.76 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL16346033 | 0.76 | ROCK2 (0.65) | ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3016951-B1 | TRICYCLIC PYRIDO-CARBOXAMIDE DERIVATIVES AS ROCK INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-05-31 | — | — | EP | disclosed |